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Navigable Slide Index

1. Introduction
2. Environmental disease process
3. Occupational disease process
4. Types of biomarkers
5. What do we mean by exposure?
6. Exposure-biomarker dose relationships
7. Toxicokinetics and models
8. Modeling the kinetics: simple model
9. Model results
10. Application of biomarkers: defining biomarker utility
11. Example: gasoline additives
12. Concern: human health risks
13. Purposes of physiologic modeling
14. Internal kinetics of an inhalation exposure
15. PBTK: model structure
16. PBTK: genetic effects on biomarkers
17. Inter-individual variation
18. Differences by route of entry
19. Common biomarkers - different kinetics
20. Human laboratory exposures
21. Subjects for the MTBE study: Larry to the rescue
22. Human exposure study
23. Toxicokinetics: MTBE, blood data
24. Toxicokinetics: TBA metabolite, blood data
25. Toxicokinetic findings
26. MTBE acute effects
27. Study limitations
28. Key points
29. Thank you

Topics Covered

• Biomarkers as indicators of exposure, adverse effects or susceptibility for an individual
• Methods of exposure: inhalation, ingestion or skin absorption
• Toxicokinetics as a guide to understanding biomarker behaviour
• Calibration of biomarkers
• Example of using biomarkers for exposure to MTBE in gasoline
• Using a physiologically based toxicokinetic (PBTK) model of MTBE to estimate tissue and biomarker levels
• Metabolic gene-environment interaction in biomarker production
• Using lab exposures to study biomarkers and the dose-response relationship

Links

Series:

• Gene-Environment Interactions

Categories:

• Clinical Practice

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on June 22, 2016

Financial Disclosures

• Prof. Thomas Smith has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.