• Statistical Genetics of Complex Diseases
• 38 min
  1. Population genetics considerations

  • Prof. Nan Laird
• 39 min
  2. Gene-by-environment interaction: study designs and analytical methods

  • Prof. L. Adrienne Cupples
• 59 min
  3. Analysis of SNP haplotypes

  • Prof. Lyle Palmer
• 36 min
  4. Statistical issues in epidemiological studies of gene-environment interaction

  • Dr. Peter Kraft
  • Prof. Donna Spiegelman
• Molecular Epidemiology of Pulmonary Diseases
• 57 min
  5. Molecular epidemiology of lung cancer

  • Prof. David Christiani
• 34 min
  6. Ethical issues in molecular epidemiology and studies of gene-environment interactions

  • Dr. Richard Sharp
• Autoimmune Diffuse Connective Tissue Diseases
• 29 min
  7. Environmental scleroderma: the evidence for putative triggers

  • Prof. Maureen Mayes
• Drug-Induced Disease
• 35 min
  8. Drug-induced lupus

  • Prof. Evelyn Hess
• Archived Lectures *These may not cover the latest advances in the field
• 41 min
  9. Biomarkers of exposure

  • Prof. Thomas Smith
• 43 min
  10. GIS and spatial statistics

  • Prof. Louise Ryan
• 47 min
  11. Gene-by-environment interactions in COPD

  • Prof. Edwin Silverman
• 40 min
  12. Occupational and environmental influences on the development and course of lupus

  • Dr. Glinda Cooper
• 54 min
  13. Genetic susceptibility in granulomatous disorders: chronic beryllium disease and sarcoidosis

  • Prof. Lee Newman
• 29 min
  14. Indians, twins and scleroderma: genetic and genomic studies

  • Prof. Frank Arnett
• 27 min
  15. Gene by environment interaction in asthma

  • Prof. Scott Weiss
• 42 min
  16. Molecular epidemiology of lung cancer

  • Prof. David Christiani
• 18 min
  17. Racial and ethnic variation in systemic lupus erythematosus and systemic sclerosis (scleroderma)

  • Dr. Patricia Fraser
• 47 min
  18. Infectious environmental factors and systemic lupus erythematosus

  • Prof. Judith James

Printable Handouts

PDF

Navigable Slide Index

1. Introducion
2. Outline
3. Genetics and exposure
4. Workplace immunologic disorders
5. Granulomatous disorders
6. Non-caseating granulomas
7. Non-caseating granuloma
8. Immunopathogenesis (1)
9. Immunopathogenesis (2)
10. The 'Trimolecular Complex'
11. Genetic implications
12. Granulomatous disorders: Ch 6
13. Granulomatous disorders
14. A tale of two disorders
15. Chronic Beryllium Disease (CBD)
16. CBD
17. Immunopathogenesis of CBD
18. Expression of HLA-DPB1 polymorphisms
19. Frequency of HLA -DPB1 Glu 69
20. Genetic epidemiology of CBD
21. Other genetic risk factors
22. Functional significance of genes in CBD
23. Anti-DP blocks proliferation of Be-specific T cells
24. Inhibition of Be-Induced IFN-gamma expression
25. Proliferation of CBD T-cell line to BeSO4 (1)
26. Proliferation of CBD T-cell line to BeSO4 (2)
27. Polymorphic amino acid residues of HLA-DPB1
28. Modeling of HLA-DP based on HLA-DR structure
29. TNF-alpha levels are associated with TNF genotype
30. Adaptive and innate immunity
31. Gene x environment in CBD
32. Beryllium machinist risk for CBD
33. Beryllium: exposure x Glu69
34. Non-caseating granuloma
35. Differential diagnosis (1)
36. Differential diagnosis (2)
37. Sarcoidosis
38. Epidemiology
39. Diagnostic criteria
40. Organ involvement
41. Clinical presentations
42. The challenge of sarcoidosis
43. Approach: divide and conquer
44. Genetic 'suspects' in sarcoidosis
45. Clinical subsets clarify genetic susceptibility
46. Clues from familial study
47. Combined effect of HLA-DR3, CCR2
48. TNF-alpha-307A polymorphism carrier frequencies
49. Lofgren's syndrome: population attributable risk
50. Genetics in discovering cause of sarcoidosis
51. T-cell antigen receptor usage in Lofgren
52. Strategy to find cause of Lofgren
53. Immunologic proof
54. Conclusions
55. References: beryllium (1)
56. References: beryllium (2)
57. References: beryllium (3)
58. References: beryllium (4)
59. References: beryllium (5)
60. References: sarcoidosis (1)
61. References: sarcoidosis (2)
62. References: sarcoidosis (3)
63. References: sarcoidosis (4)
64. References: other

Topics Covered

• Role of genetics x exposure in environmental lung disease
• Granulomatous disorders and immunologic mechanistic basis: berylliosis and sarcoidosis
• Immunogenetics that may apply generally to granulomatous disorders
• Berylliosis: genetic epidemiology studies, functional genomics and gene x environment interaction studies
• Role of exposure vs. genetic basis
• Sarcoidosis: genetic epidemiology studies, attempts at functional genomics and directions for research to use clinical phenotype and genotype information to improve and help direct the search for an unknown causative agent
• Possible implications for other (non-granulomatous) environmental lung disorders

Links

Series:

• Gene-Environment Interactions

Categories:

• Genetics & Epigenetics

Therapeutic Areas:

• Respiratory Diseases

Talk Citation

Newman, L. (2007, October 1). Genetic susceptibility in granulomatous disorders: chronic beryllium disease and sarcoidosis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 22, 2024, from https://doi.org/10.69645/TWJI9881.
Export Citation (RIS)

Publication History

• Published on October 1, 2007
• Archived on September 8, 2015

Financial Disclosures

• Prof. Lee Newman has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.