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Navigable Slide Index

1. Introducion
2. Outline
3. Genetics and exposure
4. Workplace immunologic disorders
5. Granulomatous disorders
6. Non-caseating granulomas
7. Non-caseating granuloma
8. Immunopathogenesis (1)
9. Immunopathogenesis (2)
10. The 'Trimolecular Complex'
11. Genetic implications
12. Granulomatous disorders: Ch 6
13. Granulomatous disorders
14. A tale of two disorders
15. Chronic Beryllium Disease (CBD)
16. CBD
17. Immunopathogenesis of CBD
18. Expression of HLA-DPB1 polymorphisms
19. Frequency of HLA -DPB1 Glu 69
20. Genetic epidemiology of CBD
21. Other genetic risk factors
22. Functional significance of genes in CBD
23. Anti-DP blocks proliferation of Be-specific T cells
24. Inhibition of Be-Induced IFN-gamma expression
25. Proliferation of CBD T-cell line to BeSO4 (1)
26. Proliferation of CBD T-cell line to BeSO4 (2)
27. Polymorphic amino acid residues of HLA-DPB1
28. Modeling of HLA-DP based on HLA-DR structure
29. TNF-alpha levels are associated with TNF genotype
30. Adaptive and innate immunity
31. Gene x environment in CBD
32. Beryllium machinist risk for CBD
33. Beryllium: exposure x Glu69
34. Non-caseating granuloma
35. Differential diagnosis (1)
36. Differential diagnosis (2)
37. Sarcoidosis
38. Epidemiology
39. Diagnostic criteria
40. Organ involvement
41. Clinical presentations
42. The challenge of sarcoidosis
43. Approach: divide and conquer
44. Genetic 'suspects' in sarcoidosis
45. Clinical subsets clarify genetic susceptibility
46. Clues from familial study
47. Combined effect of HLA-DR3, CCR2
48. TNF-alpha-307A polymorphism carrier frequencies
49. Lofgren's syndrome: population attributable risk
50. Genetics in discovering cause of sarcoidosis
51. T-cell antigen receptor usage in Lofgren
52. Strategy to find cause of Lofgren
53. Immunologic proof
54. Conclusions
55. References: beryllium (1)
56. References: beryllium (2)
57. References: beryllium (3)
58. References: beryllium (4)
59. References: beryllium (5)
60. References: sarcoidosis (1)
61. References: sarcoidosis (2)
62. References: sarcoidosis (3)
63. References: sarcoidosis (4)
64. References: other

Topics Covered

• Role of genetics x exposure in environmental lung disease
• Granulomatous disorders and immunologic mechanistic basis: berylliosis and sarcoidosis
• Immunogenetics that may apply generally to granulomatous disorders
• Berylliosis: genetic epidemiology studies, functional genomics and gene x environment interaction studies
• Role of exposure vs. genetic basis
• Sarcoidosis: genetic epidemiology studies, attempts at functional genomics and directions for research to use clinical phenotype and genotype information to improve and help direct the search for an unknown causative agent
• Possible implications for other (non-granulomatous) environmental lung disorders

Links

Series:

• Gene-Environment Interactions

Categories:

• Genetics & Epigenetics

Therapeutic Areas:

• Respiratory Diseases

Talk Citation

Newman, L. (2007, October 1). Genetic susceptibility in granulomatous disorders: chronic beryllium disease and sarcoidosis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 18, 2024, from https://hstalks.com/bs/83/.
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Publication History

• Published on October 1, 2007
• Archived on September 8, 2015

Financial Disclosures

• Prof. Lee Newman has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.