• Statistical Genetics of Complex Diseases
• 38 min
  1. Population genetics considerations

  • Prof. Nan Laird
• 39 min
  2. Gene-by-environment interaction: study designs and analytical methods

  • Prof. L. Adrienne Cupples
• 59 min
  3. Analysis of SNP haplotypes

  • Prof. Lyle Palmer
• 36 min
  4. Statistical issues in epidemiological studies of gene-environment interaction

  • Dr. Peter Kraft
  • Prof. Donna Spiegelman
• Molecular Epidemiology of Pulmonary Diseases
• 57 min
  5. Molecular epidemiology of lung cancer

  • Prof. David Christiani
• 34 min
  6. Ethical issues in molecular epidemiology and studies of gene-environment interactions

  • Dr. Richard Sharp
• Autoimmune Diffuse Connective Tissue Diseases
• 29 min
  7. Environmental scleroderma: the evidence for putative triggers

  • Prof. Maureen Mayes
• Drug-Induced Disease
• 35 min
  8. Drug-induced lupus

  • Prof. Evelyn Hess
• Archived Lectures *These may not cover the latest advances in the field
• 41 min
  9. Biomarkers of exposure

  • Prof. Thomas Smith
• 43 min
  10. GIS and spatial statistics

  • Prof. Louise Ryan
• 47 min
  11. Gene-by-environment interactions in COPD

  • Prof. Edwin Silverman
• 40 min
  12. Occupational and environmental influences on the development and course of lupus

  • Dr. Glinda Cooper
• 54 min
  13. Genetic susceptibility in granulomatous disorders: chronic beryllium disease and sarcoidosis

  • Prof. Lee Newman
• 29 min
  14. Indians, twins and scleroderma: genetic and genomic studies

  • Prof. Frank Arnett
• 27 min
  15. Gene by environment interaction in asthma

  • Prof. Scott Weiss
• 42 min
  16. Molecular epidemiology of lung cancer

  • Prof. David Christiani
• 18 min
  17. Racial and ethnic variation in systemic lupus erythematosus and systemic sclerosis (scleroderma)

  • Dr. Patricia Fraser
• 47 min
  18. Infectious environmental factors and systemic lupus erythematosus

  • Prof. Judith James

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Outline
3. COPD: definition
4. Spirometry: normal and COPD
5. Cigarette smoking campaign
6. Trends in cigarette smoking: men and women
7. COPD epidemiology and significance
8. FEV1 and pack year of smoking
9. Evidence for genetic determinants
10. Overview of complex trait genetics
11. Genotype by environment interaction
12. Example: Phenylketonuria
13. Does COPD fit to the 2*2 table?
14. Application of the 2*4 table
15. Types of environmental exposures
16. GxE: key issues
17. Key methods in genetic epidemiology
18. Alpha 1-antitrypsin: background
19. Alpha 1-antitrypsin deficiency and COPD
20. Variable expression in PI Z subjects
21. Pulmonary function in AAT deficiency
22. Effects of cigarette smoking
23. PI and smoking interaction
24. FEV1 in PI ZZ nonsmokers
25. Augmentation therapy
26. Who should be tested for AAT deficiency?
27. Is current AAT detection working?
28. AAT diagnosis and management
29. Testing COPD patients for AAT deficiency
30. Monogenic syndromes with COPD
31. Familial aggregation in COPD
32. Boston early-onset COPD study population
33. Results of the study
34. Phenotypes with smoking related effects
35. Genetics of pulmonary function - COPD
36. Linkage analysis of COPD related phenotypes
37. Genome scan linkage analysis
38. Genotyping and data cleaning
39. Original genome scan linkage results
40. Impact of flanking STR markers
41. Impact of stratifying by smoking
42. FEV1 linkage with Flanking markers
43. Summary of Boston results
44. Linkage analysis: Framingham study methods
45. Framingham study results
46. Linkage studies in the general population
47. Explanations for differences in linkage analysis
48. Overview of COPD fine mapping
49. Genetic association analysis of COPD
50. Case-control genetic association studies
51. Potential causes of inconsistent results
52. Testing candidate genes: phenotypes
53. Testing candidate genes: statistics
54. Testing candidate genes: populations
55. Linkage of chromosome 19 to Pre-BD FEV1
56. TGFBeta1 and COPD
57. PBAT analysis of TGFB1 SNPs
58. Case-control association analysis
59. Is TGFB1 a COPD susceptibility gene?
60. Inclusion of GxE interactions in COPD
61. Can we use the environment to find genes?
62. Collaborators

Topics Covered

• Chronic Obstructive Pulmonary Disease (COPD) and cigarette smoking
• Gene x environment interactions in COPD
• Alpha 1-antitrypsin as a rare major genetic risk for COPD
• Familial aggregation of COPD within smokers
• Linkage analysis of COPD-related phenotypes
• Genetic association studies in COPD

Links

Series:

• Gene-Environment Interactions

Categories:

• Genetics & Epigenetics

Therapeutic Areas:

• Respiratory Diseases

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on September 4, 2015

Financial Disclosures

• Prof. Edwin Silverman has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.