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- Architecture of the ribosome RNA-protein machine assembly
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2. Assembly of the 30S ribosomal subunit in vitro and in cells
- Prof. James Williamson
- Decoding and peptide bond formation
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3. How aminoacyl-tRNA synthetases translate the genetic code
- Dr. Stephen Cusack
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5. Elongation of protein synthesis: structural basis of the process of decoding
- Prof. Marina Rodnina
- Initiation of protein synthesis
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7. Factor independent initiation of protein synthesis by IRES RNAs
- Prof. Jeffrey Kieft
- Elongation and termination of protein synthesis
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8. Translocation: movement of tRNA and mRNA through the ribosome
- Prof. Harry Noller
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9. Recoding: getting more out of the message by shifting reading frame and redefining codon meaning
- Prof. John Atkins
- Prof. Raymond Gesteland
- Co-translational protein secretion
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10. Mechanism of translocon function: current insights and models
- Prof. Arnold Driessen
- How antibiotics target the ribosome
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12. Antibiotic inhibition of ribosome function
- Dr. Daniel Wilson
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13. Structure-based drug design targeting infectious disease
- Dr. Erin Duffy
- Archived Lectures *These may not cover the latest advances in the field
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15. Introduction to the ribosome
- Prof. Anders Liljas
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16. The structure of the intact ribosome and ribosomal subunit interactions
- Dr. Jamie H. Doudna Cate
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17. Structural insights into decoding of mRNA by the ribosome
- Prof. Venki Ramakrishnan
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18. Chemistry of peptide bond formation
- Prof. Rachel Green
Printable Handouts
Navigable Slide Index
- Introduction
- The 50S ribosomal subunit: a unique drug target
- Why target the 50S ribosomal subunit?
- Analysis of antibacterial market
- Target markets
- Drug resistance mechanisms (1)
- Drug resistance mechanisms (2)
- Intracellular vs. extracellular pathogens
- Sequestration: MRSA abscess
- Sequestration: biofilm development
- Cell surfaces of Gram-positive/negative bacteria
- How do antibiotics gain entry into cells?
- Porins
- Lack of uptake: streptogramin B
- Self-promoted uptake: azithromycin
- Drug modification: inactivation
- Target modifications
- Erm genes of bacteria and producer strains
- 23S mutations conferring linezolid resistance
- 23S mutations conferring macrolide resistance
- Target modifications: rRNA operons
- Target mutations: ribosomal proteins
- Drug efflux
- Major superfamilies of transport proteins
- Illustration of drug efflux through transporters
- General considerations
Topics Covered
- Why target the 50S ribosomal subunit?
- Analysis of antibacterial market
- Mechanisms of drug resistance
- Sequestration
- How do antibiotics gain entry into cells
- Porins
- Lack of uptake
- Self-promoted uptake drug modification
- Target modifications
- Drug efflux
- Major superfamilies of transport proteins
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Sutcliffe, J. (2008, May 15). Antibiotics that target the 50S ribosome subunit: resistance and other considerations [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 20, 2025, from https://doi.org/10.69645/CMET1434.Export Citation (RIS)
Publication History
- Published on May 15, 2008
Financial Disclosures
- Dr. Joyce Sutcliffe has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
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