Registration for a live webinar on 'Innovative Vaccines and Viral Pathogenesis: Insights from Recent Monkeypox Research' is now open.
See webinar detailsWe noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
- Statistical Genetics of Complex Diseases
-
1. Population genetics considerations
- Prof. Nan Laird
-
2. Gene-by-environment interaction: study designs and analytical methods
- Prof. L. Adrienne Cupples
-
3. Analysis of SNP haplotypes
- Prof. Lyle Palmer
-
4. Statistical issues in epidemiological studies of gene-environment interaction
- Dr. Peter Kraft
- Prof. Donna Spiegelman
- Molecular Epidemiology of Pulmonary Diseases
-
5. Molecular epidemiology of lung cancer
- Prof. David Christiani
- Autoimmune Diffuse Connective Tissue Diseases
-
7. Environmental scleroderma: the evidence for putative triggers
- Prof. Maureen Mayes
- Drug-Induced Disease
-
8. Drug-induced lupus
- Prof. Evelyn Hess
- Archived Lectures *These may not cover the latest advances in the field
-
9. Biomarkers of exposure
- Prof. Thomas Smith
-
10. GIS and spatial statistics
- Prof. Louise Ryan
-
11. Gene-by-environment interactions in COPD
- Prof. Edwin Silverman
-
14. Indians, twins and scleroderma: genetic and genomic studies
- Prof. Frank Arnett
-
15. Gene by environment interaction in asthma
- Prof. Scott Weiss
-
16. Molecular epidemiology of lung cancer
- Prof. David Christiani
-
18. Infectious environmental factors and systemic lupus erythematosus
- Prof. Judith James
Printable Handouts
Navigable Slide Index
- Introduction
- Outline
- Overview of complex trait genetics
- Accomplishments of 10 years of asthma genetics
- Interaction: definitions
- Genotype-by-environment (g X e) interaction
- Types of environmental exposures
- Genotype-by-environment interaction: key issues
- Methodologic issues in g X e interaction
- Linkage analysis
- Effect of smoking stratification on lod score
- Association studies
- Issues in case control association studies
- Known g X e interactions in asthma
- Case and control selection criteria
- Asthma odds ratio vs. dosage of cigarette smoking
- CD14 and ETS exposure by Choudry et al.
- GSTM1 and ETS exposure by Gilliland et al.
- GSTM1 and ETS exposure by Kabesh et al.
- Pharmacogenetics: gene X drug interaction
- Advantages of studying g X e interactions
- Disadvantages of studying g X e interactions
- Summary
- Future directions
Topics Covered
- Interaction definition
- Types of environmental exposures
- G x E interaction: key issues and study designs
- Potential methodologic issues
- G x E interaction in linkage studies of asthma
- ADRB2, GSTM1 and CD14 and smoking
- TLR4 and endotoxin
- Asthma pharmacogenetics
- Advantages and disadvantages to studying G x E interactions
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Weiss, S. (2007, October 1). Gene by environment interaction in asthma [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 2, 2024, from https://doi.org/10.69645/UQEZ6621.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Scott Weiss has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.