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Navigable Slide Index

1. Introduction
2. Outline
3. Overview of complex trait genetics
4. Accomplishments of 10 years of asthma genetics
5. Interaction: definitions
6. Genotype-by-environment (g X e) interaction
7. Types of environmental exposures
8. Genotype-by-environment interaction: key issues
9. Methodologic issues in g X e interaction
10. Linkage analysis
11. Effect of smoking stratification on lod score
12. Association studies
13. Issues in case control association studies
14. Known g X e interactions in asthma
15. Case and control selection criteria
16. Asthma odds ratio vs. dosage of cigarette smoking
17. CD14 and ETS exposure by Choudry et al.
18. GSTM1 and ETS exposure by Gilliland et al.
19. GSTM1 and ETS exposure by Kabesh et al.
20. Pharmacogenetics: gene X drug interaction
21. Advantages of studying g X e interactions
22. Disadvantages of studying g X e interactions
23. Summary
24. Future directions

Topics Covered

• Interaction definition
• Types of environmental exposures
• G x E interaction: key issues and study designs
• Potential methodologic issues
• G x E interaction in linkage studies of asthma
• ADRB2, GSTM1 and CD14 and smoking
• TLR4 and endotoxin
• Asthma pharmacogenetics
• Advantages and disadvantages to studying G x E interactions

Links

Series:

• Gene-Environment Interactions

Categories:

• Genetics & Epigenetics

Therapeutic Areas:

• Respiratory Diseases

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on February 25, 2021

Financial Disclosures

• Prof. Scott Weiss has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.