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- Architecture of the ribosome RNA-protein machine assembly
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2. Assembly of the 30S ribosomal subunit in vitro and in cells
- Prof. James Williamson
- Decoding and peptide bond formation
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3. How aminoacyl-tRNA synthetases translate the genetic code
- Dr. Stephen Cusack
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5. Elongation of protein synthesis: structural basis of the process of decoding
- Prof. Marina Rodnina
- Initiation of protein synthesis
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7. Factor independent initiation of protein synthesis by IRES RNAs
- Prof. Jeffrey Kieft
- Elongation and termination of protein synthesis
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8. Translocation: movement of tRNA and mRNA through the ribosome
- Prof. Harry Noller
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9. Recoding: getting more out of the message by shifting reading frame and redefining codon meaning
- Prof. John Atkins
- Prof. Raymond Gesteland
- Co-translational protein secretion
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10. Mechanism of translocon function: current insights and models
- Prof. Arnold Driessen
- How antibiotics target the ribosome
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12. Antibiotic inhibition of ribosome function
- Dr. Daniel Wilson
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13. Structure-based drug design targeting infectious disease
- Dr. Erin Duffy
- Archived Lectures *These may not cover the latest advances in the field
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15. Introduction to the ribosome
- Prof. Anders Liljas
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16. The structure of the intact ribosome and ribosomal subunit interactions
- Dr. Jamie H. Doudna Cate
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17. Structural insights into decoding of mRNA by the ribosome
- Prof. Venki Ramakrishnan
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18. Chemistry of peptide bond formation
- Prof. Rachel Green
Printable Handouts
Navigable Slide Index
- Introduction
- Recoding
- Recoding features
- Codon redefinition
- Bacterial selenocysteine encoding
- Selenocysteine encoding: 50S subunit interface
- Mammalian selenocysteine: selenoprotein N
- TMV RNA
- MuLV gag stop codon redefinition
- StopGo in foot-and-mouth disease virus
- Frameshifting
- Release factor 2 frameshift: plentiful RF2
- Release factor 2 frameshift: RF2 limiting
- E-site spacing at initiation
- Conservation of RF2 shift site
- ORF architecture
- Human antizyme (+1) frameshift
- Antizyme in polyamine regulation
- Two models for Ty3 (+1) frameshifting
- dnaX frameshift - DNA Pol subunits
- "dnaX" transcriptional slippage
- Beet western yellows virus: pseudoknot
- Retroviruses - why recoding?
- HIV gag - pol frameshifting
- A frameshift signal: 4 kb 3' (1)
- A frameshift signal: 4 kb 3' (2)
- Discontiguity
- T4 gene 60 bypassing
- Ribosomal protein L9
- tmRNA trans-translation
- tmRNA-ribosome complex
- Summary
Topics Covered
- Dynamic reprogramming of genetic readout
- 3 broad types
- Change in linearity, i.e. programmed ribosomal frame shifting
- Codon redefinition, i.e. commonly "stop codons" specifying an amino acid, a standard one or selenocysteine
- Discontiguity
Talk Citation
Atkins, J. and Gesteland, R. (2008, May 15). Recoding: getting more out of the message by shifting reading frame and redefining codon meaning [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 21, 2025, from https://doi.org/10.69645/WZRW7329.Export Citation (RIS)
Publication History
- Published on May 15, 2008
Financial Disclosures
- Prof. John Atkins has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
- Prof. Raymond Gesteland has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
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