Nociplastic pain

Published on August 31, 2025   33 min

A selection of talks on Neurology

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0:00
Hello, my name is Steven Cohen. Today, I'm going to talk about nociplastic pain. I'm the Edmond I Eger Professor of Anesthesiology, Neurology, Physical Medicine and Rehabilitation, Psychiatry and Neurological Surgery at the Northwestern University Feinberg School of Medicine, and a professor at the Uniformed Services University of the Health Sciences Walter Reed National Military Medical Center in Bethesda, Maryland.
0:31
At the end of this talk, the audience should be able to identify patients and conditions associated with nociplastic pain, be familiar with the mechanisms underlying nociplastic conditions and why it's important to identify it, understand the effect that nociplastic pain has on pain treatment outcomes, and be able to improve decision-making when faced with individuals who have nociplastic pain or suspected central sensitization.
1:02
These are my disclosures. There's nothing that's relevant to this talk.
1:08
It's long been recognized that there are different types of pain. Nociceptive pain is the most common type of pain. It encompasses arthritis and most forms of back and neck pain. It results from activity in neural pathways secondary to actual or potential tissue-damaging stimuli. But it's long been recognized, for at least 250 years, that there's another type of pain, neuropathic pain. Although John Fothergill, over 250 years ago, is often credited with discovering this concept, the term probably originated much further back. For example, over 1000 years ago, Haly Abbas, the Persian scholar, described nerve pain as like bugs moving, or ants, or penetrating needles felt in one's organ with deficits in sensation and motor dysfunction similar to what happens when your foot falls asleep. The main difference between neuropathic and nociceptive pain is the absence of transduction. With neuropathic pain, nerves are directly stimulated, and it has a poor prognosis. Between eight and probably one-quarter of people with nerve injury have persistent pain afterwards. With major disruption to major nerves, it's probably even much higher. Between 15-25% of chronic pain is considered to be primarily neuropathic. But we now know that many conditions, probably most conditions, have a mixed pain phenotype.

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