• Structure of the blood-brain barrier
• 36 min
  1. The blood-brain barrier in Alzheimer’s disease

  • Dr. Anika Hartz
• 35 min
  2. Tanycytes allow a tight BBB in the median eminence

  • Prof. Esteban Rodriguez
  • Dr. Juan Luis Blazquez
  • Dr. Montserrat Guerra
• Nutrient transport
• 35 min
  3. Blood-brain barrier ion transport

  • Prof. Martha O'Donnell
• Peptides and proteins
• 37 min
  4. Ingestive peptides

  • Prof. William Banks
• 62 min
  5. Blood-brain barrier in health and disease

  • Prof. Thomas Davis
• Overcoming the blood-brain barrier obstacle
• 42 min
  6. Expression vs. function of ABC transporters at the blood-brain barrier

  • Prof. Jean-Michel Scherrmann
• 44 min
  7. The blood-brain barrier and CNS drug development

  • Dr. Danica Stanimirovic
• 34 min
  8. Transport and delivery of neurotrophic peptides and proteins across the BBB

  • Prof. Weihong Pan
• Diseases involving the blood-brain barrier
• 71 min
  9. Inflammation and immune cell entry to the central nervous system

  • Prof. Serge Rivest
• 42 min
  10. The blood-brain barrier in multiple sclerosis: a target for treatment?

  • Dr. Elga de Vries
• 24 min
  11. Ischemic blood-brain barrier and Alzheimer's amyloid plaques development

  • Prof. Ryszard Pluta
• Latest Developments in the Field
• 31 min
  12. MRI approaches for neurovascular imaging

  • Dr. Rick Dijkhuizen
• 33 min
  13. Brain-gut interactions in obesity 1

  • Prof. Weihong Pan
• 19 min
  14. Brain-gut interactions in obesity 2

  • Prof. Weihong Pan
• Archived Lectures *These may not cover the latest advances in the field
• 36 min
  15. Neurotrophins and the BBB

  • Prof. Weihong Pan
• 52 min
  16. Vasoactive peptides and the blood-brain barrier

  • Prof. Maria Deli
  • Prof. Bela Kis
• 42 min
  17. In vivo systems

  • Prof. Quentin Smith
• 46 min
  18. CNS-drug design

  • Prof. Quentin Smith
• 43 min
  19. Brain-to-blood efflux transport of endogenous compounds and its analogue drug at the blood-brain barrier

  • Prof. Tetsuya Terasaki
• 23 min
  20. Stroke and the BBB

  • Prof. Marilyn Cipolla
• 54 min
  21. Barrier mechanisms in the developing brain: mechanisms and misunderstandings

  • Prof. Norman Saunders
• 57 min
  22. Barrier mechanisms in the developing brain: protection or vulnerability?

  • Prof. Norman Saunders
• 43 min
  23. In vitro models of the blood-brain barrier

  • Prof. Pierre-Olivier Couraud
• 41 min
  24. Glucose transport across the blood-brain barrier

  • Prof. Luc Leybaert
• 53 min
  25. The blood-brain barrier and brain tumors

  • Dr. Olaf van Tellingen
• 37 min
  26. Cellular composition of the blood-brain barrier

  • Prof. N. Joan Abbott
• 48 min
  27. Features of mammalian CNS barrier systems

  • Prof. Conrad Johanson

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Presentation outline
3. Brain tumors
4. Gliomas
5. Glioblastoma multiforme
6. Post-mortem diagnosed GBM
7. Primary and secondary glioblastome multiforme
8. Genetic alterations involved in GBM
9. Brain cancer and cancer stem cells
10. Chemotherapy
11. The blood-brain barrier
12. Brain tumors and disrupted barriers
13. Current treatment options for high-grade gliomas
14. Temozolomide
15. Inhibition of angiogenesis
16. Angiogenesis and glioma
17. Targeted therapies for glioma
18. Circumventing the BBB
19. Intra-ventricular therapy
20. Intra-cerebral implants
21. Convection-enhanced delivery
22. Osmotic disruption of the BBB
23. Selective opening by vaso-active compounds
24. Targeted drug delivery
25. Inhibition of drug efflux transporters
26. Efficacy of P-glycoprotein
27. Expression of ABC transporters at the BBB (1)
28. Expression of ABC transporters at the BBB (2)
29. Impact of BCRP on the brain penetration of drugs
30. Impact of BCRP on topotecan brain penetration
31. Impact of BCRP on erlotinib brain penetration
32. Intracranial tumor models for drug efficacy studies
33. CE-MRI characterization of the blood-brain barrier
34. Bioluminescence monitoring of intracranial tumors
35. Efficacy of temozolomide
36. Testing the impact of P-gp in the BBB
37. Docetaxel efficacy on intra-cranial xenografts (1)
38. Docetaxel efficacy on intra-cranial xenografts (2)
39. Docetaxel efficacy on intra-cranial xenografts (3)
40. Docetaxel efficacy on intra-cranial xenografts (4)
41. Tumor tissue drug levels
42. Staining for BBB markers in U87 tumor vessels
43. Effect of elacridar on brain penetration of docetaxel
44. Conclusions (1)
45. Conclusions (2)
46. Acknowledgements

Topics Covered

• The blood-brain barrier (BBB)
• Brain tumors/glioblastoma multiforme
• Pathobiology
• Therapeutic option with chemotherapy
• Targeted therapies
• Circumvention of the BBB
• Drug transporters
• Preclinical models

Links

Series:

• The Blood-Brain Barrier

Categories:

• Cancer
• Neuroscience

Therapeutic Areas:

• Neurology
• Oncology

Talk Citation

Publication History

• Published on March 1, 2008
• Archived on October 28, 2018

Financial Disclosures

• Dr. Olaf van Tellingen has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.