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Printable Handouts
Navigable Slide Index
- Introduction
- Presentation outline
- Brain tumors
- Gliomas
- Glioblastoma multiforme
- Post-mortem diagnosed GBM
- Primary and secondary glioblastome multiforme
- Genetic alterations involved in GBM
- Brain cancer and cancer stem cells
- Chemotherapy
- The blood-brain barrier
- Brain tumors and disrupted barriers
- Current treatment options for high-grade gliomas
- Temozolomide
- Inhibition of angiogenesis
- Angiogenesis and glioma
- Targeted therapies for glioma
- Circumventing the BBB
- Intra-ventricular therapy
- Intra-cerebral implants
- Convection-enhanced delivery
- Osmotic disruption of the BBB
- Selective opening by vaso-active compounds
- Targeted drug delivery
- Inhibition of drug efflux transporters
- Efficacy of P-glycoprotein
- Expression of ABC transporters at the BBB (1)
- Expression of ABC transporters at the BBB (2)
- Impact of BCRP on the brain penetration of drugs
- Impact of BCRP on topotecan brain penetration
- Impact of BCRP on erlotinib brain penetration
- Intracranial tumor models for drug efficacy studies
- CE-MRI characterization of the blood-brain barrier
- Bioluminescence monitoring of intracranial tumors
- Efficacy of temozolomide
- Testing the impact of P-gp in the BBB
- Docetaxel efficacy on intra-cranial xenografts (1)
- Docetaxel efficacy on intra-cranial xenografts (2)
- Docetaxel efficacy on intra-cranial xenografts (3)
- Docetaxel efficacy on intra-cranial xenografts (4)
- Tumor tissue drug levels
- Staining for BBB markers in U87 tumor vessels
- Effect of elacridar on brain penetration of docetaxel
- Conclusions (1)
- Conclusions (2)
- Acknowledgements
Topics Covered
- The blood-brain barrier (BBB)
- Brain tumors/glioblastoma multiforme
- Pathobiology
- Therapeutic option with chemotherapy
- Targeted therapies
- Circumvention of the BBB
- Drug transporters
- Preclinical models
Links
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Talk Citation
van Tellingen, O. (2008, March 1). The blood-brain barrier and brain tumors [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 7, 2024, from https://doi.org/10.69645/XZVZ7644.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Olaf van Tellingen has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.