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1. Introduction
2. Presentation outline
3. Brain tumors
4. Gliomas
5. Glioblastoma multiforme
6. Post-mortem diagnosed GBM
7. Primary and secondary glioblastome multiforme
8. Genetic alterations involved in GBM
9. Brain cancer and cancer stem cells
10. Chemotherapy
11. The blood-brain barrier
12. Brain tumors and disrupted barriers
13. Current treatment options for high-grade gliomas
14. Temozolomide
15. Inhibition of angiogenesis
16. Angiogenesis and glioma
17. Targeted therapies for glioma
18. Circumventing the BBB
19. Intra-ventricular therapy
20. Intra-cerebral implants
21. Convection-enhanced delivery
22. Osmotic disruption of the BBB
23. Selective opening by vaso-active compounds
24. Targeted drug delivery
25. Inhibition of drug efflux transporters
26. Efficacy of P-glycoprotein
27. Expression of ABC transporters at the BBB (1)
28. Expression of ABC transporters at the BBB (2)
29. Impact of BCRP on the brain penetration of drugs
30. Impact of BCRP on topotecan brain penetration
31. Impact of BCRP on erlotinib brain penetration
32. Intracranial tumor models for drug efficacy studies
33. CE-MRI characterization of the blood-brain barrier
34. Bioluminescence monitoring of intracranial tumors
35. Efficacy of temozolomide
36. Testing the impact of P-gp in the BBB
37. Docetaxel efficacy on intra-cranial xenografts (1)
38. Docetaxel efficacy on intra-cranial xenografts (2)
39. Docetaxel efficacy on intra-cranial xenografts (3)
40. Docetaxel efficacy on intra-cranial xenografts (4)
41. Tumor tissue drug levels
42. Staining for BBB markers in U87 tumor vessels
43. Effect of elacridar on brain penetration of docetaxel
44. Conclusions (1)
45. Conclusions (2)
46. Acknowledgements

Topics Covered

• The blood-brain barrier (BBB)
• Brain tumors/glioblastoma multiforme
• Pathobiology
• Therapeutic option with chemotherapy
• Targeted therapies
• Circumvention of the BBB
• Drug transporters
• Preclinical models

Links

Series:

• The Blood-Brain Barrier

Categories:

• Cancer
• Neuroscience

Therapeutic Areas:

• Neurology
• Oncology

Talk Citation

Publication History

• Published on March 1, 2008
• Archived on October 28, 2018

Financial Disclosures

• Dr. Olaf van Tellingen has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.