• Structure of the blood-brain barrier
• 36 min
  1. The blood-brain barrier in Alzheimer’s disease

  • Dr. Anika Hartz
• 35 min
  2. Tanycytes allow a tight BBB in the median eminence

  • Prof. Esteban Rodriguez
  • Dr. Juan Luis Blazquez
  • Dr. Montserrat Guerra
• Nutrient transport
• 35 min
  3. Blood-brain barrier ion transport

  • Prof. Martha O'Donnell
• Peptides and proteins
• 37 min
  4. Ingestive peptides

  • Prof. William Banks
• 62 min
  5. Blood-brain barrier in health and disease

  • Prof. Thomas Davis
• Overcoming the blood-brain barrier obstacle
• 42 min
  6. Expression vs. function of ABC transporters at the blood-brain barrier

  • Prof. Jean-Michel Scherrmann
• 44 min
  7. The blood-brain barrier and CNS drug development

  • Dr. Danica Stanimirovic
• 34 min
  8. Transport and delivery of neurotrophic peptides and proteins across the BBB

  • Prof. Weihong Pan
• Diseases involving the blood-brain barrier
• 71 min
  9. Inflammation and immune cell entry to the central nervous system

  • Prof. Serge Rivest
• 42 min
  10. The blood-brain barrier in multiple sclerosis: a target for treatment?

  • Dr. Elga de Vries
• 24 min
  11. Ischemic blood-brain barrier and Alzheimer's amyloid plaques development

  • Prof. Ryszard Pluta
• Latest Developments in the Field
• 31 min
  12. MRI approaches for neurovascular imaging

  • Dr. Rick Dijkhuizen
• 33 min
  13. Brain-gut interactions in obesity 1

  • Prof. Weihong Pan
• 19 min
  14. Brain-gut interactions in obesity 2

  • Prof. Weihong Pan
• Archived Lectures *These may not cover the latest advances in the field
• 36 min
  15. Neurotrophins and the BBB

  • Prof. Weihong Pan
• 52 min
  16. Vasoactive peptides and the blood-brain barrier

  • Prof. Maria Deli
  • Prof. Bela Kis
• 42 min
  17. In vivo systems

  • Prof. Quentin Smith
• 46 min
  18. CNS-drug design

  • Prof. Quentin Smith
• 43 min
  19. Brain-to-blood efflux transport of endogenous compounds and its analogue drug at the blood-brain barrier

  • Prof. Tetsuya Terasaki
• 23 min
  20. Stroke and the BBB

  • Prof. Marilyn Cipolla
• 54 min
  21. Barrier mechanisms in the developing brain: mechanisms and misunderstandings

  • Prof. Norman Saunders
• 57 min
  22. Barrier mechanisms in the developing brain: protection or vulnerability?

  • Prof. Norman Saunders
• 43 min
  23. In vitro models of the blood-brain barrier

  • Prof. Pierre-Olivier Couraud
• 41 min
  24. Glucose transport across the blood-brain barrier

  • Prof. Luc Leybaert
• 53 min
  25. The blood-brain barrier and brain tumors

  • Dr. Olaf van Tellingen
• 37 min
  26. Cellular composition of the blood-brain barrier

  • Prof. N. Joan Abbott
• 48 min
  27. Features of mammalian CNS barrier systems

  • Prof. Conrad Johanson

Printable Handouts

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Navigable Slide Index

1. Introduction
2. BBB is an impediment in CNS drug development
3. CNS drug development
4. The evolving concept of the blood-brain barrier
5. Neurovascular unit as an integrated concept
6. Tight junctions form the 'physical' barrier
7. The transport systems of the blood-brain barrier
8. Strategies to deliver drugs into the brain (1)
9. Strategies to deliver drugs into the brain (2)
10. Strategies to deliver drugs into the brain (3)
11. Routes for drug delivery across the BBB
12. Transcellular lipophilic diffusion
13. Inhibition of efflux pumps
14. Paracellular hydrophilic diffusion
15. Carrier-mediated transport
16. Adsorptive endocytosis
17. Receptor-mediated transcytosis
18. The molecular 'Trojan horses' concept
19. 'Trojan horses'
20. HIR as a 'Trojan horse' for drug delivery to the brain
21. 'Trojan horses' and nanocarriers
22. Considerations in designing 'Trojan horses'
23. Discovery and development of novel 'Trojan horses'
24. Single domain antibodies
25. Single-domain antibody phage display libraries
26. Selection of the BBB - targeting sdAbs
27. Brain-targeting single-domain antibodies
28. Mechanisms of transport
29. Linking molecules to FC5
30. In vivo biodistribution of FC5
31. Improving FC5 pharmacokinetics
32. Brain accumulation of FC5 formulations
33. Detection of FC5 in brain tissues
34. Detection of FC5 by confocal microscopy (1)
35. Detection of FC5 by confocal microscopy (2)
36. Summary
37. FC5-functionalized liposomes
38. Delivery using FC5-functionalized liposomes (1)
39. Delivery using FC5-functionalized liposomes (2)
40. Tailoring BBB delivery strategies (1)
41. Tailoring BBB delivery strategies (2)

Topics Covered

• Restrictive nature of the blood-brain barrier
• Non-vascular routes for brain drug delivery
• Vascular routes for brain drug delivery
• Concept of Trojan horses
• Discovery of novel receptor-mediated transcytosis routes across the blood-brain barrier
• Principles of blood-brain barrier vector development in experimental models

Links

Series:

• The Blood-Brain Barrier

Categories:

• Neuroscience
• Pharmaceutical Sciences

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on March 1, 2008

Financial Disclosures

• Dr. Danica Stanimirovic has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.