• Structure of the blood-brain barrier
• 36 min
  1. The blood-brain barrier in Alzheimer’s disease

  • Dr. Anika Hartz
• 35 min
  2. Tanycytes allow a tight BBB in the median eminence

  • Prof. Esteban Rodriguez
  • Dr. Juan Luis Blazquez
  • Dr. Montserrat Guerra
• Nutrient transport
• 35 min
  3. Blood-brain barrier ion transport

  • Prof. Martha O'Donnell
• Peptides and proteins
• 37 min
  4. Ingestive peptides

  • Prof. William Banks
• 62 min
  5. Blood-brain barrier in health and disease

  • Prof. Thomas Davis
• Overcoming the blood-brain barrier obstacle
• 42 min
  6. Expression vs. function of ABC transporters at the blood-brain barrier

  • Prof. Jean-Michel Scherrmann
• 44 min
  7. The blood-brain barrier and CNS drug development

  • Dr. Danica Stanimirovic
• 34 min
  8. Transport and delivery of neurotrophic peptides and proteins across the BBB

  • Prof. Weihong Pan
• Diseases involving the blood-brain barrier
• 71 min
  9. Inflammation and immune cell entry to the central nervous system

  • Prof. Serge Rivest
• 42 min
  10. The blood-brain barrier in multiple sclerosis: a target for treatment?

  • Dr. Elga de Vries
• 24 min
  11. Ischemic blood-brain barrier and Alzheimer's amyloid plaques development

  • Prof. Ryszard Pluta
• Latest Developments in the Field
• 31 min
  12. MRI approaches for neurovascular imaging

  • Dr. Rick Dijkhuizen
• 33 min
  13. Brain-gut interactions in obesity 1

  • Prof. Weihong Pan
• 19 min
  14. Brain-gut interactions in obesity 2

  • Prof. Weihong Pan
• Archived Lectures *These may not cover the latest advances in the field
• 36 min
  15. Neurotrophins and the BBB

  • Prof. Weihong Pan
• 52 min
  16. Vasoactive peptides and the blood-brain barrier

  • Prof. Maria Deli
  • Prof. Bela Kis
• 42 min
  17. In vivo systems

  • Prof. Quentin Smith
• 46 min
  18. CNS-drug design

  • Prof. Quentin Smith
• 43 min
  19. Brain-to-blood efflux transport of endogenous compounds and its analogue drug at the blood-brain barrier

  • Prof. Tetsuya Terasaki
• 23 min
  20. Stroke and the BBB

  • Prof. Marilyn Cipolla
• 54 min
  21. Barrier mechanisms in the developing brain: mechanisms and misunderstandings

  • Prof. Norman Saunders
• 57 min
  22. Barrier mechanisms in the developing brain: protection or vulnerability?

  • Prof. Norman Saunders
• 43 min
  23. In vitro models of the blood-brain barrier

  • Prof. Pierre-Olivier Couraud
• 41 min
  24. Glucose transport across the blood-brain barrier

  • Prof. Luc Leybaert
• 53 min
  25. The blood-brain barrier and brain tumors

  • Dr. Olaf van Tellingen
• 37 min
  26. Cellular composition of the blood-brain barrier

  • Prof. N. Joan Abbott
• 48 min
  27. Features of mammalian CNS barrier systems

  • Prof. Conrad Johanson

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Vasoactive peptides
3. Specific characteristics of the BBB
4. Angiotensins
5. Effects of angiotensin II
6. Angiotensins and the BBB
7. Effects of other angiotensins
8. Angiotensinogen-deficient mice
9. BBB and renin-angiotensin system
10. Bradykinin
11. Effects of bradykinin
12. B2 agonist transiently opens the BBB
13. Calcitonin peptide superfamily
14. Heterodimeric receptors for CGRP and AM
15. Adrenomedullin
16. Primary cultures of the BBB cells
17. Adrenomedullin production
18. BBB model based on cell culture
19. Astrocytes induce AM secretion from CEC
20. AM concentration in the cerebral circulation
21. AM acts mostly in autocrine or paracrine manner
22. AM increases intracellular cAMP level in CEC
23. AM increases TEER in brain endothelial cells
24. Effect of chronic AM treatment on TEER
25. Effects of AM on cerebral endothelial permeability
26. AM activates P-glycoprotein efflux pump in CEC
27. AM protects against oxidative damage in CEC
28. Summary: AM and the BBB
29. AM and the BBB model
30. AM regulates endothelial permeability
31. Calcitonin-gene related peptide
32. CGRP overexpression in brain
33. CGRP and the BBB
34. Endothelins family
35. The effects of endothelins
36. Endothelins and the BBB
37. Endothelins and BBB efflux pumps
38. Natriuretic peptides (NPs)
39. The effects of natriuretic peptides
40. Natriuretic peptides and the BBB
41. Pituitary adenylate cyclase activating peptide
42. Effects of PACAP
43. PACAP increases tightness of the barrier in CEC
44. Substance P
45. Effects of substance P
46. Substance P and the BBB
47. Urotensin
48. Vasopressin
49. Effects of vasopressin
50. AVP stimulates the BBB Na-K-Cl cotransport
51. Summary
52. Acknowledgements

Topics Covered

• Blood-brain-barrier (BBB) functions, permeability pathways and transporters modulated by vasoactive peptides
• The BBB as a source and target of vasocative peptides
• Angiotensins
• Bradykinin
• Adrenomedullin
• Calcitonin-gene related peptide
• Endothelins
• Natriuretic peptides
• Pituitary adenylate cyclase activating peptide
• Substance P
• Urotensin
• Vasopressin
• Potential use of vasocative peptides as modulators of BBB functions

Links

Series:

• The Blood-Brain Barrier

Categories:

• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on March 1, 2008
• Archived on September 14, 2017

Financial Disclosures

• Prof. Maria Deli has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
• Prof. Bela Kis has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.