• Structure of the blood-brain barrier
• 36 min
  1. The blood-brain barrier in Alzheimer’s disease

  • Dr. Anika Hartz
• 35 min
  2. Tanycytes allow a tight BBB in the median eminence

  • Prof. Esteban Rodriguez
  • Dr. Juan Luis Blazquez
  • Dr. Montserrat Guerra
• Nutrient transport
• 35 min
  3. Blood-brain barrier ion transport

  • Prof. Martha O'Donnell
• Peptides and proteins
• 37 min
  4. Ingestive peptides

  • Prof. William Banks
• 62 min
  5. Blood-brain barrier in health and disease

  • Prof. Thomas Davis
• Overcoming the blood-brain barrier obstacle
• 42 min
  6. Expression vs. function of ABC transporters at the blood-brain barrier

  • Prof. Jean-Michel Scherrmann
• 44 min
  7. The blood-brain barrier and CNS drug development

  • Dr. Danica Stanimirovic
• 34 min
  8. Transport and delivery of neurotrophic peptides and proteins across the BBB

  • Prof. Weihong Pan
• Diseases involving the blood-brain barrier
• 71 min
  9. Inflammation and immune cell entry to the central nervous system

  • Prof. Serge Rivest
• 42 min
  10. The blood-brain barrier in multiple sclerosis: a target for treatment?

  • Dr. Elga de Vries
• 24 min
  11. Ischemic blood-brain barrier and Alzheimer's amyloid plaques development

  • Prof. Ryszard Pluta
• Latest Developments in the Field
• 31 min
  12. MRI approaches for neurovascular imaging

  • Dr. Rick Dijkhuizen
• 33 min
  13. Brain-gut interactions in obesity 1

  • Prof. Weihong Pan
• 19 min
  14. Brain-gut interactions in obesity 2

  • Prof. Weihong Pan
• Archived Lectures *These may not cover the latest advances in the field
• 36 min
  15. Neurotrophins and the BBB

  • Prof. Weihong Pan
• 52 min
  16. Vasoactive peptides and the blood-brain barrier

  • Prof. Maria Deli
  • Prof. Bela Kis
• 42 min
  17. In vivo systems

  • Prof. Quentin Smith
• 46 min
  18. CNS-drug design

  • Prof. Quentin Smith
• 43 min
  19. Brain-to-blood efflux transport of endogenous compounds and its analogue drug at the blood-brain barrier

  • Prof. Tetsuya Terasaki
• 23 min
  20. Stroke and the BBB

  • Prof. Marilyn Cipolla
• 54 min
  21. Barrier mechanisms in the developing brain: mechanisms and misunderstandings

  • Prof. Norman Saunders
• 57 min
  22. Barrier mechanisms in the developing brain: protection or vulnerability?

  • Prof. Norman Saunders
• 43 min
  23. In vitro models of the blood-brain barrier

  • Prof. Pierre-Olivier Couraud
• 41 min
  24. Glucose transport across the blood-brain barrier

  • Prof. Luc Leybaert
• 53 min
  25. The blood-brain barrier and brain tumors

  • Dr. Olaf van Tellingen
• 37 min
  26. Cellular composition of the blood-brain barrier

  • Prof. N. Joan Abbott
• 48 min
  27. Features of mammalian CNS barrier systems

  • Prof. Conrad Johanson

Printable Handouts

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Navigable Slide Index

1. Introduction
2. The blood-brain barrier
3. The neurovascular unit
4. Physiological functions within the NVU
5. Pathways across the BBB
6. The glucose uniporter family
7. GLUTs in the brain
8. Glucose transporters in the BBB
9. GLUT-1 deficiency syndrome
10. Brain energy substrates
11. Glucose hurdles in the NVU (1)
12. Lower GLUT-1 densities in astrocytes than in BBB
13. Glucose hurdles in the NVU (2)
14. Properties of BBB glucose transport
15. Baseline glucose utilization and transport
16. Transporter densities and glucose utilization
17. A simple and widely used transport model
18. Glucose concentrations
19. Kinetic transport parameters
20. GLUT-1 topology and kinetic constants
21. BBB glucose transport - baseline setpoint
22. Glucose transport in baseline and during activation
23. Neurovascular coupling (NVC)
24. Feeding our thoughts
25. Neurometabolic coupling (NMC) (1)
26. Astrocyte-neuron lactate shuttle
27. Neurometabolic coupling (NMC) (2)
28. Coupling in the NVU
29. Neurobarrier coupling (NBC)
30. Possibilities to stimulate BBB glucose transport
31. Analysis of the LMA effect (1)
32. Glucose dynamics following brain activation
33. Analysis of the LMA effect (2)
34. Glycogen in brain astrocytes
35. Glucose transport at the next hurdle
36. In vitro evidence for G transport modulation
37. In vivo evidence for GLUT-1 stimulation
38. Mechanisms for GLUT-1 stimulation
39. Considerations on G transport
40. Two roadmaps for G to arrive at the neurons
41. BBB GLUT-1 transporters
42. Conclusion

Topics Covered

• Functions of the neurovascular unit
• Brain energy substrates
• Pathways across the blood-brain barrier
• Glucose utilization and transport
• Glucose uniporters
• Kinetic transport parameters
• Glucose transport in baseline and during activation
• Neurovascular coupling
• Neurometabolic coupling
• Neurobarrier coupling
• Dynamic changes of glucose concentration
• GLUT-1 stimulation in vitro and in vivo
• Roadmaps for glucose from blood to neurons

Links

Series:

• The Blood-Brain Barrier

Categories:

• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on March 1, 2008
• Archived on October 28, 2018

Financial Disclosures

• Prof. Luc Leybaert has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.