Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Outline
3. Gene by environment interaction - definitions
4. Gene by environment interaction - examples
5. Study designs and types of measures
6. Study designs
7. Dichotomous traits - classical case-control study
8. Case-control study - odds ratio
9. Case-only study
10. Example - case-control and case-only studies
11. Additive vs. multiplicative scales
12. Case-only vs. case-control studies
13. Discordant affected twin studies
14. Discordant affected twin studies - odds ratio
15. Study designs: issues
16. Study designs: family studies
17. G x e interactions vs. genetic heterogeneity
18. Genetic heterogeneity - examples
19. Genetic heterogeneity
20. Linkage analyses strategies
21. Ordered subsets - goal and strategy
22. Desighning ordered subsets
23. Ordered subset - evaluating significance
24. Ordered subset - example
25. Ordered subset - graph for example
26. G x e stratified analysis - goal
27. G x e stratified analysis - example
28. G x e stratified analysis - graph for example
29. Variance component g x e modeling
30. Extension of the model
31. Tests for interactions
32. G x e modeling - example
33. Polygenic model
34. Results of the modeling
35. Model's conclusions
36. Pedigree-based association analysis
37. Pedigree-based association analysis - variables
38. PBAT - test based on score statistics
39. PBAT - example
40. PBAT - results of example
41. Summary

Topics Covered

• Study designs that evaluate the joint effects of gene-by-environment interactions, including case-control, case only, matched pairs, random samples and family studies
• Distinguishing between gene-by-environment interaction and genetic heterogeneity
• Description of analytical procedures and effect measures for evaluation of gene-by-environment interaction for dichotomous and continuous outcomes
• Case-control, case only, ordered subset, variance component and PBAT analyses

Links

Series:

• Gene-Environment Interactions

Categories:

• Genetics & Epigenetics
• Methods

Talk Citation

Cupples, L.A. (2007, October 1). Gene-by-environment interaction: study designs and analytical methods [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 18, 2025, from https://doi.org/10.69645/UBBC4199.
Export Citation (RIS)

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. L. Adrienne Cupples has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.