• Introduction and General Properties of Plasmids
• 31 min
  1. Introduction to plasmid biology

  • Prof. Emeritus Don Clewell
• 39 min
  2. General properties and applications of plasmids

  • Prof. Emeritus Don Clewell
• Replication
• 47 min
  3. Plasmids: copy number control by antisense RNAs

  • Prof. Gerhart Wagner
• 30 min
  4. Plasmid rolling-circle (RC) replication

  • Prof. Saleem Khan
• 45 min
  5. Replication of linear plasmids in bacteria

  • Prof. George Chaconas
• Maintenance and Partitioning
• 32 min
  6. Plasmid segregation and stability in bacteria

  • Prof. Barbara Funnell
• 33 min
  7. Plasmid stabilization by cell killing

  • Prof. Keith Weaver
• 30 min
  8. Dimer catastrophes and plasmid resolution

  • Dr. David Summers
• Conjugation and Mobilization
• 41 min
  9. The diversity of bacterial conjugation and mobilization systems

  • Prof. Fernando de la Cruz
• 36 min
  10. The pCF10-encoded pheromone response: cell-cell signaling, complexity and evolution

  • Prof. Gary Dunny
• 27 min
  11. DNA processing in conjugative transfer

  • Dr. Joel Schildbach
• 43 min
  12. Agrobacterium tumefaciens

  • Dr. Stephen Winans
• Genetic Traits Frequently Associated with Plasmids
• 37 min
  13. Insertion sequences and DNA transposition

  • Prof. William Reznikoff
• 48 min
  14. Plasmids, integrons and the spread of antibiotic resistance

  • Prof. Hatch Stokes
• 30 min
  15. Virulence plasmids

  • Prof. Julian Rood
• Eukaryotic Plasmids
• 30 min
  16. The yeast plasmid: a highly persistent selfish DNA element

  • Prof. Makkuni Jayaram
• Population Biology and Evolution
• 35 min
  17. Evolution of plasmids and their role in bacterial diversity and adaptability

  • Prof. Christopher Thomas
• Archived Lectures *These may not cover the latest advances in the field
• 85 min
  18. Bacterial extrachromosomal elements: role in chemical detoxification and potential cancer therapy

  • Prof. Ananda Chakrabarty
• 34 min
  19. Plasmid segregation and stability in bacteria

  • Prof. Barbara Funnell
• 39 min
  20. Replication of linear plasmids in bacteria

  • Prof. George Chaconas

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Why are bacterial plasmids important?
3. Plasmids - selective forces and beneficial traits
4. Transfer systems evolve faster on plasmids
5. Plasmids and gene exchange
6. Transfer apparatuses promote biofilm formation
7. Recombination processes and plasmid diversity
8. Evidence of past integration events
9. Lessons from bacterial genetics
10. Annual succession in a microcosm
11. Habitats of Pseudomonas species
12. Pseudomonas plasmids
13. Diverse plasmid families - incompatibility groups
14. An Incp-9 plasmid - pWWO
15. An IncP-6 plasmid - Rms149
16. Plasmid backbones
17. Acquisition and clustering of plasmid functions
18. Deletions and insertions during clustering
19. Examples of clusters of basic functions
20. IncP-9-alpha basic replicon organisation
21. Regulatory integration and interdependence
22. IncP-1 plasmids - RK2 is the archetype
23. Properties of IncP-1 plasmids
24. Global regulatory circuits on RK2
25. Definition of cooperativity
26. KorB can interact cooperatively with TrbA/KorA
27. Role of "orphan" KorB sites in plasmid partitioning
28. Role of "orphan" KorB sites in regulatory circuits
29. Purpose of the regulatory circuits
30. Conclusions

Topics Covered

• Why are plasmids important?
• Plasmids and gene exchange
• Pseudomonas plasmids illustrate diversity through modular structures
• Plasmid backbones and their building blocks
• IncP-1 plasmids as an example of sophisticated circuitry to extend host range and minimize burden on host

Links

Series:

• Biology and Significance of Plasmids

Categories:

• Microbiology

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Publication History

• Published on January 28, 2008

Financial Disclosures

• Prof. Christopher Thomas has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.