• Introduction and General Properties of Plasmids
• 31 min
  1. Introduction to plasmid biology

  • Prof. Emeritus Don Clewell
• 39 min
  2. General properties and applications of plasmids

  • Prof. Emeritus Don Clewell
• Replication
• 47 min
  3. Plasmids: copy number control by antisense RNAs

  • Prof. Gerhart Wagner
• 30 min
  4. Plasmid rolling-circle (RC) replication

  • Prof. Saleem Khan
• 45 min
  5. Replication of linear plasmids in bacteria

  • Prof. George Chaconas
• Maintenance and Partitioning
• 32 min
  6. Plasmid segregation and stability in bacteria

  • Prof. Barbara Funnell
• 33 min
  7. Plasmid stabilization by cell killing

  • Prof. Keith Weaver
• 30 min
  8. Dimer catastrophes and plasmid resolution

  • Dr. David Summers
• Conjugation and Mobilization
• 41 min
  9. The diversity of bacterial conjugation and mobilization systems

  • Prof. Fernando de la Cruz
• 36 min
  10. The pCF10-encoded pheromone response: cell-cell signaling, complexity and evolution

  • Prof. Gary Dunny
• 27 min
  11. DNA processing in conjugative transfer

  • Dr. Joel Schildbach
• 43 min
  12. Agrobacterium tumefaciens

  • Dr. Stephen Winans
• Genetic Traits Frequently Associated with Plasmids
• 37 min
  13. Insertion sequences and DNA transposition

  • Prof. William Reznikoff
• 48 min
  14. Plasmids, integrons and the spread of antibiotic resistance

  • Prof. Hatch Stokes
• 30 min
  15. Virulence plasmids

  • Prof. Julian Rood
• Eukaryotic Plasmids
• 30 min
  16. The yeast plasmid: a highly persistent selfish DNA element

  • Prof. Makkuni Jayaram
• Population Biology and Evolution
• 35 min
  17. Evolution of plasmids and their role in bacterial diversity and adaptability

  • Prof. Christopher Thomas
• Archived Lectures *These may not cover the latest advances in the field
• 85 min
  18. Bacterial extrachromosomal elements: role in chemical detoxification and potential cancer therapy

  • Prof. Ananda Chakrabarty
• 34 min
  19. Plasmid segregation and stability in bacteria

  • Prof. Barbara Funnell
• 39 min
  20. Replication of linear plasmids in bacteria

  • Prof. George Chaconas

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Examples of degradative plasmids (1)
3. Examples of degradative plasmids (2)
4. Examples of degradative plasmids (3)
5. Xylene and toluene degradation by TOL plasmids
6. Degradation pathway genes regulation on pWWO
7. The chloro-catechol ortho-cleavage pathway
8. Catabolic pathways/genes in 2,4-D degradation
9. Chloro-catechol and chloro-hydroxyquinol genes
10. Chemostatic evolution of 2,4,5-T degradative genes
11. Unusual genomic structure of the 2,4,5-T genes
12. Sequence characteristics of the clc element
13. Evolution of s-triazine degradative plasmids
14. Azurin as an "anticapavi" agent
15. Azurin is able to interact with different targets
16. Structural features of azurin and immunoglobulins
17. Secretion of azurin upon exposure to cancer cells
18. Is azurin secreted due to cell lysis?
19. Is azurin secretion energy dependent?
20. Other cellular components released with azurin
21. Sequences in released extrachromosomal DNA
22. Released CpG-rich DNA has anti-tumor activity

Topics Covered

• Examples of degradative plasmids
• Xylene and toluene degradation by TOL plasmids
• The chloro-catechol orthocleavage pathway
• Catabolic pathways/genes in 2,4-D degradation
• Chemostatic evolution of 2,4,5-T degradative genes
• Unusual genomic structure of the 2,4,5-T genes
• Sequence characteristics of the clc element
• Evolution of s-triazine degradative plasmids
• Azurin interaction with different targets
• Structural features of azurin and immunoglobulins
• Secretion of azurin upon exposure to cancer cells
• Sequences in released extrachromosomal DNA
• Released CpG-rich DNA has anti-tumor activity

Links

Series:

• Biology and Significance of Plasmids

Categories:

• Genetics & Epigenetics
• Methods
• Microbiology

Talk Citation

Chakrabarty, A. (2008, January 28). Bacterial extrachromosomal elements: role in chemical detoxification and potential cancer therapy [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 9, 2024, from https://doi.org/10.69645/ONWI6643.
Export Citation (RIS)

Publication History

• Published on January 28, 2008
• Archived on February 25, 2021

Financial Disclosures

• Prof. Ananda Chakrabarty has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.