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Pioneering proteomics: insights on advancements in the science of proteins

Published on June 30, 2025   14 min

A selection of talks on Methods

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Interviewer: We're joined today by Professor Rudolf Aebersold from ETH Zurich, one of the world's leading experts in proteomics and systems biology to discuss the current state of the field of proteomics. To start, what do you consider to be the most significant advancement in protein science in recent years? Prof. Aebersold: Thanks for the question. There's been a huge amount of progress in protein science at various levels. I would point out, maybe, two as the most significant. One is clearly a revolution in structural biology. Actually, there were two revolutions consecutively, the one to achieve molecular structures at atomic resolution by cryo-EM and more recently even by cryo-EM tomography to observe structures in the context of the cell. Then, of course, in the last few years the computational prediction of three-dimensional structures of proteins through AlphaFold and similar tools. Concurrently, there has been enormous progress in the measurement of proteins in terms of the proteins expressed in a cell, so this is the field of proteomics. It has now gone way beyond just measuring the presence and quantity of the proteins that are in a cell, and can now also measure, through techniques developed over the last, I would say half a decade, how these proteins are modified, how they are folded, how the fold changes in the context of the cell, how they interact with each other, and also dependencies between these attributes,

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Pioneering proteomics: insights on advancements in the science of proteins

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