• Introduction
• 3 min
  1. Editor's foreword

  • Prof. Ann Daly
• 47 min
  2. Introduction to drug metabolism enzymes

  • Dr. Dennis Smith
• General factors affecting drug metabolism
• 30 min
  3. General factors affecting drug metabolism: effect of physiological factors and disease 1

  • Prof. Edward T. Morgan
• 24 min
  4. General factors affecting drug metabolism: effect of physiological factors and disease 2

  • Prof. Edward T. Morgan
• 39 min
  5. Drug metabolism in liver disease

  • Dr. Nathalie Zgheib
  • Prof. Robert Branch
• 37 min
  6. Laboratory methods for the in vitro study of drug metabolism

  • Dr. Ritu Singh
• 50 min
  7. Prediction of pathways of drug metabolism

  • Dr. Maurice Dickins
• Phase I metabolizing enzymes: cytochrome P450s
• 45 min
  8. Cytochrome P450 1 family: the roles of 1A1, 1A2 and 1B1 in drug metabolism

  • Prof. F. Peter Guengerich
• 42 min
  9. CYP2 family

  • Prof. Ann Daly
• 52 min
  10. Why study the cytochrome P4503A (CYP3A) family?

  • Dr. Erin Schuetz
• 54 min
  11. Pharmacogenomics: an update

  • Prof. Magnus Ingelman-Sundberg
• Phase I metabolizing enzymes: non-cytochrome P450s
• 45 min
  12. Non-P450 oxidative metabolism: characteristics and drug substrates

  • Dr. Christine Beedham
• 53 min
  13. UDP-glucuronosyltransferases

  • Prof. Abby Collier
• Phase II metabolizing enzymes: conjugating enzymes
• 31 min
  14. Glutathione transferases

  • Prof. Ralf Morgenstern
• 31 min
  15. Arylamine N-acetyltransferases 1

  • Prof. Edith Sim
• 23 min
  16. Arylamine N-acetyltransferases 2

  • Prof. Edith Sim
• 19 min
  17. Arylamine N-acetyltransferases 3

  • Prof. Edith Sim
• 56 min
  18. Methyltransferases

  • Prof. Richard Weinshilboum
• 22 min
  19. Amino acid conjugation: mechanism and enzymology

  • Dr. Kathleen Knights
• Clinical aspects
• 33 min
  20. Clinical significance of enzyme induction and inhibition

  • Prof. Kim Brøsen
• 39 min
  21. Clinical importance of pharmacogenetic polymorphisms affecting drug metabolism

  • Prof. Julia Stingl (formerly Kirchheiner)
• Latest Updates in the Field
• 34 min
  22. Mammalian flavin-containing monooxygenases

  • Prof. Allan Rettie
• Archived Lectures *These may not cover the latest advances in the field
• 54 min
  23. Glucuronidation and the UDP - glucuronosyltransferases

  • Prof. Peter Mackenzie
  • Prof. John Miners
• 38 min
  24. General factors affecting drug metabolism: the role of nuclear receptor superfamily members in induction

  • Dr. Patrick Maurel
• 28 min
  25. Catalytic cycle of cytochrome P450s

  • Prof. Gordon Roberts
• 40 min
  26. Drug metabolism and liver disease

  • Prof. Robert Branch
• 46 min
  27. Crystal structures of drug-metabolizing P450 monooxygenases

  • Prof. Eric Johnson
• 49 min
  28. Sulfation and human cytosolic sulfotransferases

  • Prof. Charles Falany
• 50 min
  29. Laboratory methods for the in vitro study of drug metabolism

  • Dr. Charles Crespi
• 45 min
  30. Clinical importance of pharmacogenetic polymorphisms affecting drug metabolism: psychopharmacology and pain

  • Prof. Julia Stingl (formerly Kirchheiner)
• 51 min
  31. Genetic variability in Paraoxonase 1 (PON1), an HDL associated esterase: impact on risk and pharmacokinetics

  • Res. Prof. Clement Furlong
• 53 min
  32. Pharmacogenomics

  • Prof. Magnus Ingelman-Sundberg

Printable Handouts

PDF

Navigable Slide Index

1. Methyltransferases
2. Picture of Wilhelm His
3. Methylation of pyridine
4. S-adenosyl-L-methionine
5. Picture of Giulio Cantoni
6. Methionine metabolism
7. Methylation pharmacogenomics
8. Methltransferases - substrates
9. Methyltransferases - enzymes
10. COMT-catalyzed methylation
11. Picture of Julie Axelrod
12. Dopamine catabolism
13. Human COMT gene and mRNA
14. Rat COMT crystal structure
15. Methyltransferase structures (1)
16. Methyltransferase structures (2)
17. Human RBC COMT
18. Human COMT
19. E-COMT activity & 3OMD/LD conc.
20. Human COMT alleles
21. Human liver COMT
22. Human COMT polymorphisms
23. Human COMT allozyme activity (1)
24. Human COMT allozyme activity (2)
25. COMT and schizophrenia
26. Methyltransferases - enzymes
27. Metabolism of 6-mercaptopurine
28. Picture
29. Pharmacogenomic guidance
30. Human RBC TPMT
31. Low/high TPMT
32. Selected human TPMT alleles
33. TPMT gene structure
34. Human TMPT allozyme activity
35. Human TPMT protein (1)
36. Human TPMT protein (2)
37. TMPT genetic polymorphism
38. Aggreosme formation
39. TMPT aggreosme formation
40. TPMT colocalization
41. Protein fold./degrad./aggreg.
42. Methyltransferases - enzymes
43. PNMT - formation of epinephrine
44. Methyltransferase gene structure
45. PNMT polymorphisms
46. PNMT allozyme functional studies
47. PNMT allozyme transl./degrad.
48. PNMT Ala98 allozyme degrad.
49. Methyltransferases - enzymes
50. NNMT
51. Methyltransferase gene structure
52. Methyltransferases - enzymes
53. INMT
54. Methyltransferase gene structure
55. Methltransferases - enzymes
56. Histamine
57. Picture of Henry Dale
58. Histamine metabolism
59. Human HNMT gene
60. Histamine and asthma
61. Methyltransferases - enzymes
62. Picture
63. Arsenic biotransformation
64. Human AS3MT polymorphisms
65. Methyltransferases - enzymes
66. Picture of Wilhelm His
67. Picture of Julie Axelrod
68. S-adenosyl-L-methionine
69. Methionine metabolism

Topics Covered

• Properties, structure, catalytic cycle, isoforms and drug substrate specificity of the main methyltransferase families contributing to drug metabolism
• Regulation of gene expression
• Pharmacogenetics

Links

Series:

• Drug Metabolizing Enzymes

Categories:

• Biochemistry
• Metabolism & Nutrition
• Pharmaceutical Sciences

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Publication History

• Published on October 30, 2007
• Reviewed on August 29, 2019

Financial Disclosures

• Prof. Richard Weinshilboum has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.