We noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
Printable Handouts
Navigable Slide Index
- Glucuronidation and UGT
- Content of presentation
- The glucuronidation reaction
- UDP-glucuronic acid
- Glucuronidation reaction scheme
- Glucuronidation - detox. mechanism
- UGT substrates - aliphatic alcohols
- UGT substrates - phenols
- UGT substrates - carboxylic acids
- UGT substrates - amines
- UGT substrates - thiols and AC
- Sites for glucuronidation
- Compounds eliminated by glucur.
- Human UGTs
- Substrate selectivity of human UGTs
- UGT1A pharmacophores
- UGT isoform expression
- UGT isoform selectivity of bilirubin
- UGT isoform selectivity of testos.
- UGT isoform selectivity of trifluop.
- UGT isoform selectivity of AZT
- UGT substrate selectivity
- UGT gene family
- UGT1 family
- UGT2 family
- Topology model and dimerization
- UGT domains
- Topology model
- Dimerization of UGT
- Dimerization of UGT - implications
- UGT gene expression
- Tissue-specific expression of UGTs
- UGT gene expression
- Hepatic UGT2B gene transcription
- UGT2B proximal promoters
- UGT1A7-10 gene transcription
- UGT structure-function relationship
- The human UGT1A gene locus
- UGT2B2/UGT2B3 hybrid proteins
- Binding domain of UGT2B15
- Structural domains of UGT
- UGT genetic polymorphism
- Disorders of bilirubin glucuronidation
- UGT1A1 polymorphism
- UGT1A1 - TA repeat number
- Effect of UGT1A1*6 (G71R)
- UGT1A1 allele frequencies
- Influence of UGT2B15 genotype
- UGTs and adverse events
- Kinetics of xenobiotic glucur. in vitro
- Bisubstrate kinetics
- UGT kinetics - empirical models
- Zidovudine glucuronidation
- 4-methylumbelliferone glucur.
- "Two site" kinetic model
- 4-methylumbelliferone glucur.
- UGT inhibition and drug interactions
- Effect of fluconazole on UGT
- Hecogenin - inhibitor of UGT1A4
- Human hepatic UGT isoforms
- Inhibition of human UGTs
- Drug interactions
- UGT reviews
- Contact
Topics Covered
- The glucuronidation reaction
- UGT enzyme superfamily
- Importance for xenobiotic and drug metabolism
- Substrate and inhibitor specificities
- Gene regulation
- Tissue specific expression
- Genetic polymorphism
- Structure/function relationships
- Kinetic considerations
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Mackenzie, P. and Miners, J. (2007, October 1). Glucuronidation and the UDP - glucuronosyltransferases [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 10, 2024, from https://doi.org/10.69645/MFGX4670.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Peter Mackenzie has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
- Prof. John Miners has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.