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Navigable Slide Index

1. Intro slide
2. The central dogma of molecular biology
3. Eukaryotes process their RNA
4. Studies of the individual steps of gene expression
5. Transcription, RNA export & processing are linked
6. Coordination of events in gene expression pathway
7. The capping process
8. The splicing process
9. The polyadenylation process
10. Polyadenylation and termination are coupled
11. The RNA polymerase II C-terminal domain (CTD)
12. CTD phosphorylation during transcription
13. CTD phosphorylation controls protein binding
14. Advantages of using the CTD as a scaffold (1)
15. Advantages of using the CTD as a scaffold (2)
16. Advantages of using the CTD as a scaffold (3)
17. Capping and the ordering of processing events
18. Splicing depends upon recognition of sequences
19. Splicing in multi-intron genes
20. RNA processing occurs during transcription
21. RNA is prepared for export during transcription
22. RNA export
23. Advantages of linking export to processing
24. Summary
25. Transcription and alternative splicing (1)
26. Transcription and alternative splicing (2)
27. Promoter effects on alternative splicing
28. Enabling alternative splice site usage (1)
29. Enabling alternative splice site usage (2)
30. Polar effects in splicing
31. Factors that regulate elongation (1)
32. Factors that regulate elongation (2)
33. Challenges to studying linkages between steps
34. Genome-wide analysis of gene expression
35. Analysis of gene expression (1)
36. Analysis of gene expression (2)
37. Clustering splicing microarray data
38. Classify expression defects
39. Conclusions
40. Further reading

Topics Covered

• Mechanistic coupling of RNA processing, export and transcription
• Current evidence supporting coupling mechanisms
• Role of the RNA polymerase II CTD
• Competition during transcription between RNA binding proteins
• Future challenges and directions

Links

Series:

• Eukaryotic Gene Regulation

Categories:

• Cell Biology
• Genetics & Epigenetics

Talk Citation

Hartzog, G. (2007, October 1). Coupling transcription, RNA processing and RNA export [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 22, 2024, from https://doi.org/10.69645/RYAB6026.
Export Citation (RIS)

Publication History

• Published on October 1, 2007
• Archived on April 13, 2022

Financial Disclosures

• Prof. Grant Hartzog has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.