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1. Intro slide
2. Regulation of gene expression
3. Mammalian gene transcription control elements
4. Yeast gene transcription control elements
5. Activators are modular proteins
6. Regulation of transcription factor (TF) activity
7. The glucocorticoid receptor
8. The estrogen receptor
9. Indirect regulation of TFs
10. PKs in TFs' regulation
11. The Ci and beta-catenin TFs
12. IL2 regulation
13. The PLC gamma pathway
14. c-Jun and c-Fos are unstable proteins
15. IL2 regulation
16. IFN - beta
17. Activators interact with promoter binding proteins
18. NtrC interacts with 54 polymerase
19. Cellular DNA is bound with proteins in chromatin
20. Chromatin condensation
21. Heterochromatin and euchromatin
22. Chromatin condensation
23. The nucleosome (1)
24. The nucleosome (2)
25. The histone tails
26. Amino acid modifications on chromatin
27. Histone acetylase complexes
28. Activator-directed histone hyperacetylation
29. The co-activator CBP
30. Chromatin remodeling factors
31. Chromatin remodeling factors and a nucleosome
32. Chromatin decondensation
33. Heterochromatin visualized in CHO cells
34. Euchromatin visualization in CHO cells
35. Eukaryotic repressors are modular proteins
36. HDACs and chromatin condensation
37. The mediator complex
38. EM visualization of mediator and RNA Pol II
39. The yeast mediator complex
40. The human mediator complex
41. Activator binding to regulatory element
42. Formation of the pre-initiation complex
43. The scaffold complex
44. Transcription initiation by the mediator
45. Mediator interaction with other activation domains
46. Regulation of transcription initiation

Topics Covered

• Transcription by RNA polymerase II
• Mediator complex
• Coactivator proteins
• Communication between DNA-binding proteins and general transcription machinery

Links

Series:

• Eukaryotic Gene Regulation

Categories:

• Cell Biology
• Genetics & Epigenetics

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on April 17, 2016

Financial Disclosures

• Prof. Arnold Berk has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.