Gene structure, expression and regulation: DNA structure and replication
37 min
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- Introduction to Protein Structure and Function
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40 min
1. Nature’s strategies in the regulation of enzyme activity by modifiers- Prof. Antonio Baici
- Creation of Protein Variability by Manipulation of Genes
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28 min
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48 min
3. Perspectives on biological catalysis- Prof. Stephen Benkovic
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45 min
4. Fundamentals and principles for engineering proteolytic activity- Prof. Charles Craik
- Metabolic Diseases Caused by Genetic Mutation
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36 min
5. Modifications of pyruvate handling in health and disease- Prof. Mary Sugden
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29 min
6. Mitochondrial fatty acid oxidation deficiencies- Prof. Niels Gregersen
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33 min
7. Inborn errors of ketone body metabolism- Prof. Toshiyuki Fukao
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34 min
8. Cathepsin K in bone and joint diseases- Prof. Dieter Bromme
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22 min
9. Fabry disease: alfa-galactosidase A deficiency and enzyme replacement therapy- Prof. David Warnock
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47 min
10. Acid beta-glucosidase/glucocerebrosidase (GCase)- Prof. Gregory Grabowski
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23 min
11. GM2 gangliosidosis future treatments 1- Prof. Brian Mark
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19 min
12. GM2 gangliosidosis future treatments 2- Prof. Brian Mark
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29 min
13. The neuronal ceroid lipofuscinoses- Prof. Sandra Hofmann
- Disorders of Blood Coagulation
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24 min
14. Advances in fibrinolysis- Dr. Paul Kim
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26 min
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36 min
16. Structure of thrombin, a Janus-headed proteinase- Prof. Wolfram Bode
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45 min
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40 min
18. Fibrinogen and factor XIII- Prof. John Weisel
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31 min
19. Factor VIII and haemophilia A- Dr. Geoffrey Kemball-Cook
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34 min
20. Factor IX- Prof. Bruce Furie
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42 min
21. The biology and pathobiology of von Willebrand factor- Prof. David Lillicrap
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40 min
22. Thrombotic thrombocytopenic purpura- Prof. J. Evan Sadler
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26 min
23. Fibrinolysis- Prof. Edward Tuddenham
- Other Molecular and Metabolic Disorders
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45 min
24. Glucose-6-phosphate dehydrogenase deficiency- Dr. Jane Leopold
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26 min
25. Cytochrome b5 reductase deficiency and hereditary methemoglobinemia- Dr. Scott Reading
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50 min
26. Sickle cell disease- Prof. Martin H. Steinberg
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40 min
27. Pyruvate kinase deficiency- Prof. Alberto Zanella
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47 min
28. Heritable disorders of collagen- Dr. Heather Yeowell
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40 min
29. Duchenne muscular dystrophy- Prof. Jeff Chamberlain
- Archived Lectures *These may not cover the latest advances in the field
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33 min
30. Protein crystallography- Prof. Michael James
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48 min
31. Regulation of blood coagulation by the serpin, antithrombin- Prof. Steve Olson
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37 min
32. Rhodopsin and retinitis pigmentosa- Dr. Shalesh Kaushal
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40 min
33. The physiology and pathology of coagulation factor XI- Dr. David Gailani
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24 min
34. Cytochrome b5 reductase deficiency and hereditary methemoglobinemia- Prof. Josef Prchal
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49 min
35. Metachromatic leukodystrophy- Prof. Volkmar Gieselmann
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21 min
36. Serpins and serpinopathies- Dr. James Whisstock
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27 min
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39 min
38. Pleiotropic and epistatic genes in sickle cell anaemia- Prof. Ronald Nagel
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44 min
39. Genetic disorders of carbonic anhydrases II and IV- Prof. William Sly
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39 min
40. GM2 gangliosidoses- Prof. Don Mahuran
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48 min
41. Kinetic analysis of protein activity- Prof. Antonio Baici
Printable Handouts
Navigable Slide Index
- Introduction
- G6PD - a "housekeeping" enzyme
- G6PD gene structure (1)
- G6PD and X-inactivation
- G6PD gene structure (2)
- G6PD promoter
- G6PD protein
- G6PD protein and NADP binding
- G6PD enzymology
- G6PD - pentose synthesis vs. oxidant stress
- G6PD - oxidant stress and apoptosis
- Regulations of G6PD expression and activity
- Tissue specific G6PD expression
- G6PD deficiency (1)
- G6PD and positive selection by malaria
- Common variants
- Worldwide distribution of G6PD deficiency
- G6PD gene mutations
- WHO biochemical classification
- Methods to identify G6PD deficiency
- G6PD deficiency (2)
- G6PD deficiency and hemolysis (1)
- G6PD deficiency and hemolysis (2)
- Treatment options
- G6PD, other cell types and disease states
- Role of G6PD in neutrophil function (1)
- Role of G6PD in neutrophil function (2)
- Role of G6PD in neutrophil function (3)
- G6PD and sepsis after severe injury
- G6PD deficiency and risk of diabetes
- Diabetes and acquired G6PD deficiency
- Hyperglycemia decreases G6PD activity (1)
- Hyperglycemia decreases G6PD activity (2)
- G6PD and hypertension
- G6PD and gestational hypertension
- G6PD as an antioxidant in non-erythrocytic cells
- G6PD and vascular endothelial cells (EC)
- G6PD and vescular EC oxidant stress
- G6PD-deficient EC and vascular oxidant stress
- G6PD-deficient EC and nitric-oxide (1)
- G6PD-deficient EC and nitric-oxide (2)
- G6PD deficiency and EC migration
- G6PD deficiency and tube formation
- In vivo matrigel assay
- G6PD deficiency and vascular reactivity (1)
- Brachial artery vascular reactivity
- G6PD deficiency and vascular reactivity (2)
- G6PD and cytosolic redox states in myocytes
- G6PD and ischemia - reperfusion
- Summary
Topics Covered
- G6PD and X-chromosome
- Genetics
- Protein structure and function
- G6PD and neutrophil function/inflammation
- Role of G6PD in diabetes mellitus
- Hypertension
- G6PD modulates vascular oxidant stress
- Angiogenesis is regulated by G6PD activity
- G6PD and vascular reactivity
- G6PD, cardiomyocytes and ischemia-reperfusion
Links
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Talk Citation
Leopold, J. (2007, October 1). Glucose-6-phosphate dehydrogenase deficiency [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved February 5, 2025, from https://doi.org/10.69645/BDMJ5168.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Jane Leopold has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Glucose-6-phosphate dehydrogenase deficiency
Published on October 1, 2007
45 min
