Protein Degradation

Published on October 1, 2007 Reviewed on January 19, 2016   55 min

Other Talks in the Series: From DNA to Proteins

In today's lecture, we're going to be discussing the cellular mechanisms for degrading intracellular proteins and the biological importance of this process. Thus far in the course, you've been concerned with systems for expression of genetic information. The central dogma of modern biology is shown in the next slide. This slide emphasizes that cell proteins are being
made off messenger RNA molecules encoded in DNA. And the general assumption until recently was once proteins are made, they are stable structures that basically live happily ever after. Today we'd like to disabuse you of this comfortable idea and replace it with another view of the cell. This revised view emphasizes that proteins,
once synthesized, are short lived structure. Their lives are nasty, brutish and short. And this rapid destruction of cell proteins, although seemingly highly wasteful, is absolutely essential for viability.