Chromatin architecture and alterations in the control of gene regulation

Published on October 1, 2007 Reviewed on January 19, 2016   44 min

Other Talks in the Series: From DNA to Proteins

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Chromatin Architecture and the Regulation of Gene Expression prepared and presented by Jeffrey Hansen, Professor of Biochemistry and Molecular Biology, Colorado State University. Hello and welcome to
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the presentation on Chromatin Architecture and the Control of Gene Expression. This talk is organized into six sections. I begin with a brief overview of Chromatin Architecture and its relevance to Gene Expression in Eukaryotic organisms. I then, describe in more detail the many different levels of chromatin organization found in interphase chromosomes. As a transition into Gene Expression, I highlight three Milestone Experiments, each of which established that transcription in Eukaryotes is fundamentally dependent on chromatin structure. This is followed by a large section that focuses on the Regulation of Gene Expression through Alteration of Chromatin Architecture. I end by emphasizing the dynamic nature of the genome in vivo, and by highlighting important future questions in this area. My overall objective is to further your understanding of chromatin structure, and its many roles in determining how Eukaryotic genomes are organized and deciphered.
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An overview of Chromatin Architecture and Gene Expression. The Multiple Levels of Chromatin Architecture present in
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interphase chromosomes are illustrated schematically on this slide. At the initial level, chromosomal DNA is wrapped around in octamer of core histones to form the nucleosome. The nucleosome is the sub-unit of chromatin. Nucleosome spaced at roughly 200 base pair intervals along the chromosomal DNA are called Nucleosomal arrays. Nucleosomal arrays complexed with a specific set of functional or structural non-histone proteins are called Chromatin fibers. Chromatin fibers are very dynamic. They can exist in a number of different folded conformations. Chromatin fibers are subsequently twisted, looped and coiled to form the 400 nanometer diameter extensively condensed chromatids present in the interphase nucleus.
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Chromatin architecture and alterations in the control of gene regulation

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