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Navigable Slide Index

1. Introduction
2. Challenges to gene finding
3. Genome wide association scan
4. Martian "face" at Cydonia Mensae
5. Computer enhanced image from Cydonia Mensae
6. Other examples of pareidolia
7. 1989: Fleischmann and Pons press conference
8. Some lessons from the last examples
9. Importance of the repeatability of effect
10. The wisdom of two-stage design
11. Example: Golub and Lander, Science, 2000
12. What is the best way to divide N samples?
13. Why not let data decide?
14. Sequential statistics
15. Sequential analysis
16. Standard repeated analysis creates new problem
17. SPRT (Sequential Probability Ratio Test)
18. "Newtonian" sequential LOD score
19. Critical test characteristics
20. Single "fixed sample" test
21. Multiple "fixed sample" tests
22. Single sequential tests
23. Disadvantage of classical sequential analysis
24. Sequential Multiple Decision Procedures (SMDP)
25. Traditional hypothesis test - H0 versus H1
26. U hypotheses in SMDP
27. Residuals from ANOVA/regression
28. SMDP theory
29. SMDP regression
30. Simulation of 400 marker genome-wide scan
31. SMDP S.A.G.E. DBH example
32. SMDP R square change with sequential sampling
33. Golub and Lander: application of SMDP
34. PGRN: pharmacogentics of cancer Rx response
35. CEPH cell line pharmacogenetics example
36. Summary: SMDP
37. References

Topics Covered

• Sequential analysis in genome wide linkage and association scans
• Sequential probability ratio test
• Sequential multiple decision procedures
• Simulation results and examples

Links

Series:

• Genetic Epidemiology II

Categories:

• Genetics & Epigenetics
• Methods

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on February 25, 2021

Financial Disclosures

• Prof. Michael Province has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.