• Special Designs
• 46 min
  1. Family-based association tests: introduction

  • Dr. Christoph Lange
• 29 min
  2. Family-based association tests: FBAT testing strategies for large-scale association studies

  • Dr. Christoph Lange
• 37 min
  3. Two-stage genome-wide association designs

  • Dr. Andrew Skol
• Special Populations
• 40 min
  4. Admixture mapping

  • Dr. Paul McKeigue
• Whole-Genome Studies: Types of Data
• 34 min
  5. QTL association mapping

  • Prof. Bruce Weir
• 50 min
  6. Adjusting for population structure in genetic association studies

  • Prof. David Balding
• Whole-Genome Studies 2: Methods
• 47 min
  7. Whole-genome association studies: practical advice and considerations

  • Dr. Mike Weale
• Archived Lectures *These may not cover the latest advances in the field
• 49 min
  8. Family-based association tests: FBATs for various data types

  • Dr. Christoph Lange
• 44 min
  9. Choosing between family-based and population-based association designs

  • Dr. Ren-Hua Chung
• 54 min
  10. Use of isolated populations: pitfalls and potential

  • Dr. Leena Peltonen
• 40 min
  11. Information on untyped variation in genome-wide association studies

  • Dr. Dan Nicolae
• 37 min
  12. Detecting multiple associations in genome-wide studies

  • Prof. Frank Dudbridge
• 30 min
  13. Genome scanning by composite likelihood

  • Dr. Andrew Collins
• 41 min
  14. Multistage sampling for genetic studies

  • Prof. Robert Elston
• 39 min
  15. Screening large-scale association study data: exploiting multi-gene interactions with random forests

  • Dr. Kathryn Lunetta
• 43 min
  16. A survey of multi-locus methods for analysis of large SNP datasets

  • Mr. A. Geert Heidema
• 34 min
  17. Sequential analysis methods in genomic scans

  • Prof. Michael Province

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Talk outline
3. Preface
4. Types of sample
5. Classical paradigm
6. Classical paradigm - 1st sampling stage
7. Classical paradigm - 2nd sampling stage
8. Classical paradigm - 3rd sampling stage
9. Classical paradigm - 4th sampling stage
10. Complex diseases
11. Linkage mapping
12. Association study samples
13. Purpose of association study
14. Information for association (1)
15. Information for association (2)
16. Two stage sampling
17. What should the first stage sample be?
18. Family samples
19. Pooled DNA samples
20. Case-control samples
21. Single stage sampling for GWA
22. Two stage sampling for GWA
23. Cost efficient two stages
24. Two stage sampling: Satagopan et al. (2002)
25. Two stage sampling: Satagopan et al. (2004)
26. Two stage sampling: Satagopan and Elston (2003)
27. Two stage sampling: Skol et al. (2006)
28. Two stage sampling: Wang H et al. (2006)
29. Strategies and challenges
30. Three/multistage design (1)
31. Three/multistage design (2)
32. Summary
33. References (1)
34. References (2)

Topics Covered

• Classical paradigm for rare monogenic diseases
• Multistage designs for association studies, common complex diseases
• Random and multiplex family samples, case-control samples
• Genetic epidemiology: segregation analysis, linkage analysis, association analysis
• Sampling to minimize cost
• Multiphase analysis to increase power, multiple comparisons

Links

Series:

• Genetic Epidemiology II

Categories:

• Genetics & Epigenetics
• Methods

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on February 25, 2021

Financial Disclosures

• Prof. Robert Elston has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.