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Printable Handouts
Navigable Slide Index
- Introduction
- Association mapping for QTLs
- Quantitative traits
- Two-allele models
- Trait mean and variance
- QTL models
- Traditional model
- Traditional model moments
- Fisherian model
- Fisherian model moments
- Zeng model
- Marker loci (1)
- Marker loci (2)
- Marker-QTL frequencies
- Marker-based moments
- Traditional model: marker-based representation
- Fisherian model: marker-based representation
- Zeng model: marker-based representation
- Regression of trait on marker
- Marker-trait frequencies
- Marker data
- Trait data
- Marker-trait data
- Regression coefficients
- Marker-trait correlation
- Regression ANOVA
- Testing procedure
- Power of test (1)
- Power of test (2)
- Alternative marker variable (1)
- Alternative marker variable (2)
- Marker conditioning on trait
- Case-only Hardy-Weinberg
- Case-control comparisons (1)
- Case-control comparisons (2)
- Extensions
- References (1)
- References (2)
Topics Covered
- QTLs affect continuous traits
- Generally mapped from pedigree or family data
- Genome-wide association studies extended to QTLs
- Alternative models for genetic values
- Regress trait values on genetic markers
- Power of regression tests
- Case-control tests when QTL governs probability of affection
- Case-only Hardy-Weinberg tests
Talk Citation
Weir, B. (2007, October 1). QTL association mapping [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 26, 2024, from https://doi.org/10.69645/SBFD8213.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Bruce Weir has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.