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Navigable Slide Index

1. Introduction
2. Association mapping for QTLs
3. Quantitative traits
4. Two-allele models
5. Trait mean and variance
6. QTL models
7. Traditional model
8. Traditional model moments
9. Fisherian model
10. Fisherian model moments
11. Zeng model
12. Marker loci (1)
13. Marker loci (2)
14. Marker-QTL frequencies
15. Marker-based moments
16. Traditional model: marker-based representation
17. Fisherian model: marker-based representation
18. Zeng model: marker-based representation
19. Regression of trait on marker
20. Marker-trait frequencies
21. Marker data
22. Trait data
23. Marker-trait data
24. Regression coefficients
25. Marker-trait correlation
26. Regression ANOVA
27. Testing procedure
28. Power of test (1)
29. Power of test (2)
30. Alternative marker variable (1)
31. Alternative marker variable (2)
32. Marker conditioning on trait
33. Case-only Hardy-Weinberg
34. Case-control comparisons (1)
35. Case-control comparisons (2)
36. Extensions
37. References (1)
38. References (2)

Topics Covered

• QTLs affect continuous traits
• Generally mapped from pedigree or family data
• Genome-wide association studies extended to QTLs
• Alternative models for genetic values
• Regress trait values on genetic markers
• Power of regression tests
• Case-control tests when QTL governs probability of affection
• Case-only Hardy-Weinberg tests

Links

Series:

• Genetic Epidemiology II

Categories:

• Genetics & Epigenetics
• Methods

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. Bruce Weir has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.