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1. Introduction
2. Learning objectives
3. Definition: genetic association
4. Example 1: HIV-1 anti-body resistance
5. Example 2: number of positive skin tests
6. Example 3: Alzheimer-free survival and APOE
7. Illustration of genetic association
8. Linkage disequilibrium
9. Case-control analysis
10. Case-control analysis: testing for association
11. Samples from mixed populations
12. Population admixture: solutions
13. Case-control analysis: dichotomous trait
14. Family-based association analysis
15. Family-based association studies
16. The transmission disequilibrium test (1)
17. The transmission disequilibrium test (2)
18. The transmission disequilibrium test (3)
19. Summary of TDT
20. An alternative formula for the TDT
21. The variables of the alternative test
22. Computation using Mendelian transmission
23. An alternative formula for the TDT: FBATs
24. Limitations of FBAT/TDT approach
25. FBATs: no parental genotypes (1)
26. FBATs: no parental genotypes (2)
27. The general FBAT
28. The FBATs for quantitative traits
29. First option of phenotype coding
30. Second option of phenotype coding
31. Summary of FBATs

Topics Covered

• Definition: genetic association
• Examples
• Linkage disequilibrium
• Case-control analysis
• Samples from mixed populations
• Population admixture
• Dichotomous trait
• The transmission disequilibrium test (TDT)
• An alternative formula for the TDT: FBATs
• FBATs: no parental genotypes
• The general FBAT
• FBATs for quantitative traits

Links

Series:

• Genetic Epidemiology II

Categories:

• Genetics & Epigenetics
• Methods

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Dr. Christoph Lange has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.