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1. Introduction
2. The story of multiple sclerosis: 1838-1993
3. The symptoms of multiple sclerosis
4. Pathogenesis of MS
5. Pathogenesis of MS: possible therapies
6. Pathological hetrogeneity in MS
7. Impairment of function and the MS clinical course
8. Reduced MS activity with interferon-beta-1b
9. Pivotal trials in relapsing-remitting MS (1)
10. Pivotal trials in relapsing-remitting MS (2)
11. Cochrane analysis of interferon efficacy
12. Monoclonal antibody trialed in MS
13. Pivotal trials of ZENAPAX (daclizumab): results
14. Nataluzimab\tysabru reduces relapse rate
15. Pivotal trials of tysabri - 2 year results
16. PML with tysbari
17. The story of Campath-1H treatment
18. Campath-1H causes prolonged T-cell depletion
19. Effects of the first dose of Campath-1H
20. Axonal damage is caused before conduction block
21. Campath-1H suppresses relapses in MS
22. Effect of Campath-1H on disability
23. Comparison of trials on Campath-1H and tysbari
24. Infections after Campath-1H
25. Graves' disease after Campath-1H treatment ( 1)
26. Graves' disease after Campath-1H treatment (2)
27. Immune trombocytopenia after Campath-1H
28. Autoimmune disease after Campath-1H
29. Other examples of reconstitution autoimmunity
30. Pathology and course of MS
31. Treatment of MS - 2006 and beyond

Topics Covered

• The story of multiple sclerosis
• Symptoms
• Pathogenesis
• Pathological heterogeneity
• Axonal degeneration
• Current treatments
• Interferons and glatiramer
• Monoclonal antibody treatment of multiple sclerosis
• Daclizumab
• Natalizumab
• The story of Campath-1H
• The effect of Campath-1H on disability depends upon the stage of the disease
• Graves' disease
• Immune thrombocytopenia
• Future treatment of multiple sclerosis

Links

Series:

• Monoclonal Antibodies as Therapeutic Agents

Categories:

• Clinical Practice
• Immunology

Therapeutic Areas:

• Immunology & Inflammation
• Neurology

Talk Citation

Coles, A. and Compston, A. (2007, October 1). Antibody therapy of multiple sclerosis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/KLCK1482.
Export Citation (RIS)

Publication History

• Published on October 1, 2007

Financial Disclosures

• Dr. Alasdair Coles has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
• Prof. Alastair Compston has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.