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Restoring glucose metabolism: a new approach to reversing cognitive decline in AD

Published on February 27, 2025   17 min

A selection of talks on Neurology

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Interviewer: We are joined today by Professor Katrin Andreasson from the Stanford University School of Medicine who recently published, along with colleagues, a science paper which uncovers the way by which disruptions in brain glucose metabolism contribute to Alzheimer's disease progression. The study highlights the role of the enzyme indoleamine dioxygenase or IDO1 in suppressing neural energy supply and suggests that repurposing IDO1 inhibitors used in cancer therapy could provide a new approach for treating neurodegenerative disorders. Professor Andreasson, thank you very much for joining us today. Can you start by explaining the rationale for investigating the link between glucose metabolism and Alzheimer's disease? Prof. Andreasson: Yes. Thank you so much for this opportunity to share our work in Alzheimer's disease, and actually as we age and probably in a number of other neurodegenerative diseases the brain's glucose metabolism becomes altered. It's quite low in Alzheimer's disease in particular areas of the brain. This has been a clinical feature that we have been able to detect using FDG-PET which is a way of imaging glucose uptake in the body, in the brain, and other regions. It's known that in Alzheimer's disease, the glucose metabolism in particular areas of the brain is reduced, particularly the areas of the brain that are

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Restoring glucose metabolism: a new approach to reversing cognitive decline in AD

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