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Recognition of tumour-induced osteomalacia and emerging therapies

Published on April 30, 2025   33 min

A selection of talks on Cardiovascular & Metabolic

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0:00
Hello. My name is Nilton Salles Rosa Neto. I am a professor of rheumatology at Universidade Santo Amaro in Sao Paulo, Brazil and I also work for the Center for Rare and Immune Disorders at Hospital Nove de Julho also in Sao Paulo, Brazil. The title of my talk is recognition of tumor-induced osteomalacia and emerging therapies.
0:26
Those are my disclosures.
0:29
First, we should remember what is the composition of bone. So, bone is composed of organic matrix and mineral phase. Most of the organic matrix is composed of Type I collagen, approximately 90% and the mineral phase is mostly composed of crystals of hydroxyapatite, which is in their turn composed of calcium phosphate. Osteomalacia is a defect in the skeleton mineralisation, which will ensure bone pain, deformities, and fractures, and also patients may complain of muscle weakness. Causes of osteomalacia may be vitamin D deficiency, calcium deficiency or loss and phosphorus loss.
1:13
In this slide you can see on the left panel a bone biopsy and here you can see the normal bone. The most outer aspect is the cortical bone and the inner aspect is the trabecular bone. You can see the cortical bone is normal, thick, and the trabeculae are well-connected and thick. On the right panel, you can see a bone biopsy of a patient with osteoporosis. You can see that the cortices are thin and the trabeculae are less numerous and they are not connected to one another.

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Recognition of tumour-induced osteomalacia and emerging therapies

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