We noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
Printable Handouts
Navigable Slide Index
- Introduction
- New lymphocyte membrane proteins
- Purification of lymphocyte surface proteins
- Leukocyte membrane proteins domains (1)
- Leukocyte membrane proteins domains (2)
- Variable abundance of membrane glycoproteins
- Glycosylation of lymphocyte surface proteins
- Glycosylation of membrane proteins
- Variable size of membrane glycoproteins
- Size of membrane proteins
- mAb binds cell surface proteins very effectively
- Roles of leukocyte membrane proteins
- Identification of leukocyte surface receptors
- CD200 binds macrophages and blocked by mAb
- CD200-CD200 receptor: macrophage regulation
- Membrane protein interactions are low affinity
- Membrane protein interactions
- How do mAb work as drugs?
- Properties of mAb important
- Affinity of mAb
- Affinity of mAb: the OX7 mAb
- Affinity of mAb: the CD147 mAb
- Affinity of mAb: kinetics
- Where does the mAb bind?
- Some targets are small surface proteins
- Summary
Topics Covered
- Lymphocyte cell surface
- Membrane proteins
- Identification of interactions
- Protein microarrays
- Monoclonal antibodies
- Recombinant proteins
- Characterization of interactions at a molecular level
- Reaction kinetics
- Protein structure
- Role of engagement
- Role in disease and potential therapies
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Barclay, N. (2022, April 12). Cell surface glycoproteins on cells of the immune system [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 3, 2024, from https://doi.org/10.69645/JTGT2374.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Neil Barclay has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.