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- Epidemiology
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2. Epidemiology of obesity
- Prof. Jacob Seidell
- Etiology and Causes
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3. Metabolic, adipose tissue and muscle predictors of obesity
- Prof. Ian Macdonald
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4. Neural control of food intake and energy balance
- Prof. Hans-Rudolf Berthoud
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6. Dietary determinants of obesity
- Prof. Arne Astrup
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7. Physical inactivity as a determinant of obesity
- Prof. Wim Saris
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8. Environmental causes of obesity: sociocultural, built environment and economic factors
- Prof. Shiriki Kumanyika
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9. The developmental origins of obesity
- Prof. David Barker
- Consequences of Obesity
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10. Obesity, dyslipoproteinemia and inflammation
- Prof. Robert Eckel
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11. Pathophysiology and management of obesity related hypertension
- Prof. Arya Sharma
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12. Disorders of overeating
- Prof. Albert Stunkard
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13. Obesity, weight loss and health-related quality of life
- Prof. Aila Rissanen
- Dr. Jarmo Kaukua
- Treatment Options
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14. Lifestyle modification for weight control
- Prof. Thomas Wadden
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15. Bariatric / obesity surgery
- Prof. Henry Buchwald
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16. Can obesity be prevented in the current obesogenic environment?
- Prof. Boyd Swinburn
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17. Pharmacotherapy for obesity: why it is needed
- Prof. Joe Proietto
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18. Pharmacotherapy for obesity: hunger suppressors
- Prof. Joe Proietto
- Latest Developments in the Field
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19. Body composition
- Dr. Steven Heymsfield
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20. Adipose tissue metabolism and obesity
- Dr. Max Lafontan
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21. Obesity, present and future therapies
- Prof. Sir Stephen Bloom
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22. Energy expenditure in the lean and obese
- Prof. Dale Schoeller
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23. Obesity and adiponectin
- Prof. Philipp Scherer
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24. Ectopic fat: causes, consequences and treatment
- Prof. Steven Smith
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25. Adipose-immune interactions in obesity
- Dr. Vishwa Dixit
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26. Health benefits of intentional weight loss
- Prof. Xavier Pi-Sunyer
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27. Childhood obesity: implications for current and future health
- Prof. Peter T. Katzmarzyk
- Archived Lectures - These lectures may not cover the latest advances in the field
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29. Gastrointestinal peptides and food intake regulation
- Prof. Sir Stephen Bloom
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30. Obesity and mortality: questions and controversy
- Prof. David Allison
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31. Obesity, diabetes and the cluster of the metabolic syndrome
- Prof. Peter Wilson
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33. Health economics of obesity: new insights
- Dr. Anne Wolf
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34. Bariatric surgery: techniques and mechanisms of action
- Prof. Walter Pories
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35. Childhood obesity: implications for future health
- Prof. Peter T. Katzmarzyk
Printable Handouts
Navigable Slide Index
- Introduction
- Hunger suppressing medications
- What hunger suppressors do we have? (1)
- How do ketones suppress hunger?
- Glucose inhibits hunger
- The mechanism by which glucose inhibits hunger
- There is a second way that ketones control hunger (1)
- There is a second way that ketones control hunger (2)
- Conclusions
- What hunger suppressors do we have? (2)
- Mode of action of phentermine
- Contraindications to using phentermine
- What hunger suppressors do we have? (3)
- How does liraglutide work?
- Liraglutide increases satiety and reduces hunger via neurons in the arcuate nucleus
- Liraglutide has multifactorial effects: Pharmacological effects of liraglutide
- Liraglutide study
- Liraglutide study results
- Liraglutide study side effects
- What hunger suppressors do we have? (4)
- How does naltraxone/bupropion work? (1)
- How does naltraxone/bupropion work? (2)
- Contrave clinical development program completers data and primary end point
- Contrave (naltraxone/bupropion)
- Safety evaluated in 4754 patients up to 56 weeks
- What hunger suppressors do we have? (5)
- Semaglutide 2.4 mg/week
- Semaglutide results
- What hunger suppressors do we have? (6)
- Phentermine/topiramate (1)
- Phentermine/topiramate (2)
- Side effects
- What hunger suppressors do we have? (7)
- Medications to treat diabetes that can cause mild weight loss
- Tirzepatide 5, 10, 15 mg/week (1)
- Tirzepatide 5, 10, 15 mg/week (2)
- How do we maintain weigh loss long term? Lifestyle advice
- Major points about weight loss medications
- The team
Topics Covered
- Hunger suppressing medications
- Ketones
- Phentermine
- Liraglutide
- Naltraxone/bupropion
- Semaglutide
- Phentermine/topiramate
- Tirzepatide
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Proietto, J. (2025, February 27). Pharmacotherapy for obesity: hunger suppressors [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 21, 2025, from https://doi.org/10.69645/XXBE7050.Export Citation (RIS)
Publication History
- Published on February 27, 2025
Financial Disclosures
- Advisory Board: Novo Nordisk and iNOVA
Pharmacotherapy for obesity: hunger suppressors
Published on February 27, 2025
35 min
A selection of talks on Genetics & Epigenetics
Transcript
Please wait while the transcript is being prepared...
0:00
I'm Joe Proietto.
I am a professor emeritus at
the University of Melbourne.
This is Part 2 of
the lectures on
pharmacotherapy for obesity.
I gave my potential conflicts
of interest in Part 1.
0:21
The vigorous defense
of body weight
is the reason why obesity
must be treated with
hunger-suppressing medications
that, in fact, have to
be continued even after the
patient has lost weight.
As you saw from
the last lecture,
this may need to be lifelong.
0:45
What hunger suppressors
do we have?
First of all, there are
ketones that suppress
hunger and these are
homemade because ketones
are made in the liver.
Pharmacological agents
you can see listed there;
phentermine, liraglutide,
naltrexone/bupropion,
phentermine and topiramate,
and semaglutide 2.4 plus
some diabetes medications that
have an influence on weight.
1:22
How do ketones suppress hunger?
The brain can
metabolize ketones.
In this paper by
Stephanie Amiel and her
husband Edwin Gale,
they showed that the brain
can metabolize ketones.