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1. Introduction
2. Fibrinogen important functions
3. Basic scheme of fibrin polymerization
4. The 3 pairs of polypeptide chains of fibrinogen
5. TEM fibrinogen images
6. Structure of fibrinogen
7. Biosynthesis of fibrinogen
8. Diagram of the complementary binding sites
9. Physical model of the protofibril
10. Structure of protofibrils
11. Schematic model of complementary binding sites
12. Activation of factor XIII
13. Formation of iso-peptide bonds in fibrin
14. Factor XIII stabilizes fibrin
15. Diagram of fibrin polymerization
16. Fibrin fibers structure in TEM
17. Specimen preparation for TEM: negative contrast
18. Twisting of protofibrils around each other
19. SEM of fibrin fibers images
20. Branch points of fibrin fibers
21. SEM of fibrin clots images (1)
22. The kinetics of polymerization
23. Fibrin is a viscoelastic polymer
24. The unique mechanical properties of fibrin
25. Fibrin clot formation: turbidity curves
26. Stiffness as another measure of polymerization
27. Another way to determine stiffness
28. Binding of other proteins to fibrin(ogen)
29. Light microscope images of fibrin clots
30. SEM of fibrin clots images (2)
31. Plasminogen activation and fibrin lysis
32. Fragments from plasmin digestion of fibrin
33. Electron micrographs of fibrinolysis
34. Products of fibrinolysis
35. Fibrin-plasmin interactions leading to cleavage (1)
36. Fibrin-plasmin interactions leading to cleavage (2)
37. Fibrinogen is necessary for platelet aggregation
38. TEM images of rotary shadowed alphaIIb-beta3
39. TEM images of fibrinogen-integrin complexes
40. Illustration of platelet aggregation
41. Dysfibrinogenemias
42. Fibrinogen variants
43. Evolution of fibrinogen
44. Summary

Topics Covered

• Fibrinogen and factor XIII
• Structure
• Biosynthesis
• Fibrin polymerization
• Crosslinking
• Clot mechanical properties
• Interactions with other proteins
• Fibrinolysis
• Platelet aggregation
• Dysfibrinogenemias and variants
• Evolution

Links

Series:

• Protein Epidemiology

Categories:

• Biochemistry
• Cell Biology

Therapeutic Areas:

• Haematology

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. John Weisel has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.