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1. Introduction
2. Definition and prevalence
3. Etiopathogenesis
4. Endocrine system
5. Skin
6. Muscle
7. Bone
8. FD/MAS etiopathogenesis and histopathology
9. Periosteal bone is not primarily affected
10. Osteogenic cells form thin, irregular bone trabeculae
11. Dysplastic bone irregularly replaces normal bone
12. Dysplastic bone and fibrous tissue are highly vascularized
13. Fibroblast growth factor 23 (FGF23)
14. Skeletal involvement in FD/MAS
15. Progression of skeletal lesions in FD/MAS
16. FD/MAS malignant transformation
17. FD/MAS clinical manifestations
18. Imaging in FD/MAS: radiology and CT scan
19. Imaging in FD/MAS: MRI and Tc bone scan
20. Pain in FD/MAS
21. Typical lower limb deformities: 6 typical deformities
22. Typical lower limb deformities: other
23. Worsening of skeletal deformities in FD/MAS
24. Fractures in FD/MAS
25. Scoliosis in FD/MAS
26. FD/MAS diagnosis (1)
27. FD/MAS diagnosis (2)
28. Medical treatment: bisphosphonates
29. Medical treatment: denosumab
30. Denosumab: clinical trial
31. Denosumab: mouse models
32. Medical treatment: denosumab and zoledronic acid
33. Medical treatment: burosumab
34. Surgical treatment of FD/MAS: basic principles
35. Two stage surgery in severe coxa vara ≤90o
36. Intramedullary nailing (IN) for lower limb FD
37. Titanium elastic nails (TENs)
38. Complementary surgery: performed during growth in 37% of cases
39. Evaluation scale at follow-up
40. Results (IN in child with FD)
41. Good results: 16 years follow-up
42. Poor results
43. Complications
44. IN in patients with previous unsuccessful treatment
45. Results (IN in adults with previous unsuccessful treatment)
46. Results: good and poor
47. Complications
48. Conclusions: etiopathogenesis
49. Conclusions: diagnosis and treatment
50. Conclusions: surgery
51. Conclusions: the future
52. Acknowledgements

Topics Covered

• McCune-Albright Syndrome (MAS)
• Fibrous Dysplasia (FD)
• Etiopathogenesis of MAS
• Skeletal involvement in FD/MAS
• Imaging FD/MAS
• FD/MAS diagnosis
• FD/MAS medical treatment
• Surgical treatment of FD/MAS
• Intramedullary Nailing (IN)

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Categories:

• Clinical Practice
• Metabolism & Nutrition

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Publication History

• Published on July 31, 2024

Financial Disclosures

• There are no financial interests to disclose.
• There are no financial interests to disclose.