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Navigable Slide Index

1. Introduction
2. Prevalence of hypertension by BMI and AGE
3. Abdominal obesity and blood presure
4. Obesity and MI: case control study
5. BMI categories with MI risk: waist-to-hip ratio
6. Obesity and cardiovascular risk
7. Vital statistic: waist circumference
8. Pathophysiology of obesity hypertension
9. Hemodynamic alterations in obese adolescents
10. High fat diet causes Na retention and hypertension
11. Leptin acts as a lipostat
12. Carotid artery leptin infusion decreases food intake
13. Leptin infusion increases arterial pressure
14. Leptin in obese normotensives and hypertensives
15. Leptin and sympathetic nerve activity
16. Cardiorenal effects of obesity
17. Renin-angiotensin system in obesity
18. Renin-angiotensin genes expression in adipocytes
19. AT1 receptor expression on human adipocytes
20. Meta-Analysis of RCTs
21. Antihypertensive agents in obese hypertensives
22. Treatment of obesity hypertension
23. Trial of hypertension prevention of weight-loss arm
24. Currently approved antiobesity agents
25. Orlistat promotes clinically significant weight loss
26. Orlistat: effect on blood pressure in hypertensives
27. Study: sibutramine in obese hypertensive patients
28. Reality: CV side effects in sibutramine trials
29. BP changes in sibutramine-treated patients
30. Sympathetic stimulation: handgrip test
31. Sympathetic stimulation: cold pressor test
32. Plasma noradrenaline: supine
33. Sibutramine affects sympathetic activity
34. Sibutramine: Scout study
35. Bariatric surgery: effect on cardiovascular risk
36. Summary and Conclusions

Topics Covered

• Prevalence of hypertension
• Abdominal obesity and blood pressure
• Myocardial infarction risk
• Obesity and cardiovascular risk
• Pathophysiology of obesity hypertension
• Leptin
• Cardiorenal effects of obesity
• Renin-angiotensin system in obesity
• Treatment of obesity hypertension
• Currently approved anti-obesity agents: Orlistat and Sibutramine
• Bariatric surgery

Links

Series:

• Obesity

Categories:

• Clinical Practice
• Metabolism & Nutrition

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Sharma, A. (2007, October 1). Pathophysiology and management of obesity related hypertension [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2025, from https://doi.org/10.69645/XAQU8193.
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Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. Arya Sharma has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.