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Printable Handouts
Navigable Slide Index
- Introduction
- Patients' selection
- Gsα protein
- R201: postzygotic mutations
- MAS: Clinical presentation
- Main endocrinopathies in MAS
- Hypercortisolism
- Hypercortisolism: prevalence
- Hypercortisolism in MAS
- Adrenal evaluation in children
- Management of hypercortisolism
- Precocious puberty (1)
- Precocious puberty: prevalence
- Precocious puberty (2)
- Clinical course of precocious puberty in girls with MAS
- Natural history of precocious puberty in girls with MAS
- Historical treatment of MAS: oophorectomy
- Ovarian cysts in MAS girl
- Historic treatment of precocious puberty in girls with MAS
- Treatment of precocious puberty in girls with MAS
- Auxological data of 10 young MAS females at the study
- Retrospective data on peripheral precocious puberty of 10 MAS young females
- Ovarian function in adolescent and young females with MAS
- Menstrual cycles in 10 young MAS females in the last year before the study
- Uterus and endometrium
- Ovarian cysts
- Ovarian function in adolescent and young females with MAS (1)
- Ovarian function in adolescent and young females with MAS (2)
- MAS females: associated health risks
- MAS: implications for ovarian function
- Conclusions
- Males with MAS
- Hyperthyroidism (1)
- Hyperthyroidism: prevalence
- Hyperthyroidism (2)
- Hyperthyroidism treatment
- GH excess (1)
- GH excess: prevalence
- GH hypersecretion in MAS
- GH excess (2)
- Investigations
- Symptoms
- Treatment
- Hyperprolactinemia
- Hyperprolactinemia: prevalence
- Hyperprolactinemia in MAS
- Hyperprolactinemia treatment
- The mosaic nature of MAS
- Spectrum of clinical presentation
- MAS is a clinical spectrum
- Summary
Topics Covered
- McCune-Albright Syndrome (MAS)
- Hypercortisolism
- Precocious Puberty (PP)
- Ovarian hyperfunction in adolescent females with MAS
- Hyperthyroidism
- GH excess
- Hyperprolactinemia
Talk Citation
Lala, R. (2024, June 30). Multiple endocrine hyperfunction in McCune-Albright syndrome [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 21, 2024, from https://doi.org/10.69645/RBST7619.Export Citation (RIS)
Publication History
Financial Disclosures
- There are no commercial/financial matters to disclose.
A selection of talks on Clinical Practice
Transcript
Please wait while the transcript is being prepared...
0:00
Multiple endocrine hyperfunction
in McCune-Albright syndrome.
My name is Roberto Lala.
I am an Italian medical doctor.
I have been head of the
pediatric endocrinology unit
of Regina Margherita
Children's Hospital, Turin.
The first patient with
McCune-Albright syndrome
I met was about
three decades ago.
I have collected an
experience about
Italian patients with
McCune-Albright syndrome.
My city is Turin in Italy.
0:41
Patients' selection.
When speaking about
McCune-Albright syndrome,
you have to pay attention
to the main symptoms
which are peripheral
precocious puberty,
skin cafè-au-lait spots, and
fibrous osseous dysplasia.
These three symptoms define
the syndrome in general,
but we will see afterward
that the syndrome
is heterogeneous in size,
symptom, and expression.
McCune-Albright syndrome
contains and can
give source to multiple
endocrine hyperfunctions.
Today, we will
speak about those,
but we will not
forget that there are
several isolated endocrine
hyperfunctions also.
These are gonadal
hyperfunctions,
pituitary GH-secreting adenomas,
pituitary ACTH-secreting
adenomas,
adrenal adenomas,
thyroid nodules.