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1. Introduction
2. Lipid and lipoprotein metabolism
3. HDL metabolism
4. Obesity,dyslipidemia,inflammation and ASCVD
5. Obesity lipid/lipoprotein abnormalities
6. The consequence of increase in total cholesterol
7. And It's just not fasting TG
8. Mechanisms of hepatic fatty acid to triglyceride
9. Fatty acid metabolism
10. Regulation of lipolysis
11. The antilipolytic effect of insulin
12. Response of FFA to insulin/glucose
13. Insulin inhibition of FFA turnover
14. Insulin action in the liver
15. Is there an effect of CHO independent of insulin?
16. Effect of SRIF on FFA
17. Effect of SRIF on plasma glucose and insulin
18. Effect of SRIF on hypertriglyceridemia
19. Carbohydrate responsive elements
20. SREBP-1c dependent genes in the liver
21. ChREBP and SREBP-1c and hepatic lipogenesis
22. Plasma VLDL-TG in obese and lean men/women
23. VLDL TG kinetics in lean and obese men/women
24. Plasma VLDL-TG kinetics in men/women
25. VLDL TG clearance in lean and obese men/women
26. Adipose tissue LPL responsiveness to insulin
27. Patterns of body fat distribution
28. Visceral adiposity: the critical adipose depot
29. Visceral vs subcutaneous adipose tissue
30. Banting lecture 1998
31. The clustering of risk factors for ASCVD (2)
32. The reduction of HDL cholesterol in obese patients
33. Age-adjusted prevalence of HDL cholesterol
34. Pathogenesis of decreased HDL cholesterol
35. A reason for reductions in HDL cholesterol
36. HDL cholesterol and plasma TG
37. Plasma levels of HDL particles in the MetS
38. Production of HDL particles in the MetS
39. Clearance of HDL particles in the MetS
40. Pathogenesis of increased atherosclerosis
41. The impact of cytokines on obesity and ASCVD
42. Inflammatory markers and insulin resistance
43. Elevated CRP levels in obese adults
44. CRP in overweight and obese men and women
45. Inflammation and obesity
46. Obesity is associated with cytokine burden
47. CRP and body composition
48. Visceral adipose tissue/plasma CRP/oxidized LDL
49. Changes in metabolic syndrome components
50. BMI and CRP in adolescents
51. Weight reduction modifies dyslipidemia
52. Timing of lipid assessment is important
53. Impact of weight reduction on lipids/lipoproteins(1)
54. Impact of weight reduction on lipids/lipoproteins(2)
55. Impact of weight reduction on plasma triglycerides
56. The mechanisms for the reduction in TG in obese
57. Molar ratio of VLDL TG/Apo B-100
58. Relative change in VLDL Apo B-100 secretion
59. VLDL TG secretion: effect of weight reduction
60. Impact of weight reduction on HDL cholesterol
61. HDL cholesterol,weight reduction and stabilization
62. Impact of weight reduction on HDL2 /HDL3
63. A diet restricted in total fat lowers HDL and LDL
64. Impact of weight reduction on LDL cholesterol
65. Change in CRP after 15% weight loss
66. Effect of weight reduction on insulin sensitivity
67. Effect of weight reduction on plasma hs-CRP
68. Effect of weight reduction on interleukin-18 levels
69. Gastric bypass and cytokines at 14 Mo
70. Summary

Topics Covered

• Normal lipid and lipoprotein physiology
• Abnormalities of lipid and lipoprotein physiology in obesity and related mechanisms
• Inflammation and obesity
• The benefit of weight reduction to favorably modify plasma lipids, lipoproteins and the inflammatory burden in obese patients

Links

Series:

• Obesity

Categories:

• Clinical Practice
• Metabolism & Nutrition

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. Robert Eckel has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.