Neuropathology of neurodegenerative disorders
33 min
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
- Biochemistry
-
8 min
1. De novo designed proteins: a breakthrough in snakebite treatment- Dr. Susana Vazquez Torres
- Cancer/Oncology
-
26 min
2. From lab to clinic: bridging cancer genetics and public health- Prof. Clare Turnbull
-
21 min
3. Engineered yeast: a breakthrough in targeted cancer therapies- Prof. Gautam Dantas
-
9 min
-
18 min
5. Cancer vaccines- Dr. Elias Sayour
-
11 min
6. The future of blood tests in cancer treatment- Dr. Isaac Garcia-Murillas
-
15 min
-
14 min
8. Artificial intelligence in precision medicine- Dr. Michael P. Menden
-
18 min
9. How liver X receptor regulates intestinal regeneration and tumor growth- Dr. Srustidhar Das
- Immunology & Inflammation
-
14 min
10. Role of ETS2 in autoimmune and inflammatory diseases- Dr. James Lee
-
29 min
11. Rheumatic diseases and musculoskeletal pain- Prof. Anisur Rahman
-
13 min
-
16 min
13. Transmembrane domains and the regulation of trogocytosis in T cells- Dr. Stefano Barbera
-
12 min
- Infectious Diseases/Microbiology
-
31 min
15. Elite controllers of HIV: from discovery to future therapies- Prof. Bruce Walker
-
8 min
-
23 min
17. Towards developing a universal influenza vaccine- Prof. Peter Palese
-
10 min
- Methods
-
21 min
19. The role of preregistration and registered reports in improving research transparency and reproducibility- Dr. Peter Bonde Ernst-Rasmussen
-
17 min
20. Decoding aging: how a proteomic clock predicts mortality and disease across populations- Dr. M. Austin Argentieri
-
10 min
21. MassBank development and future- Dr. Emma L. Schymanski
-
25 min
22. Synthetic whole embryo models and their applications- Prof. Jacob (Yaqub) Hanna
-
14 min
23. Pioneering proteomics: insights on advancements in the science of proteins- Prof. Ruedi Aebersold
- Neurology/Neuroscience
-
14 min
24. Rethinking the amyloid dogma in Alzheimer’s disease- Prof. George Perry
-
8 min
25. Integrated multimodal cell atlas of Alzheimer’s disease- Dr. Michael Hawrylycz
-
17 min
26. How and why neurons die in Alzheimer's disease?- Prof. Bart De Strooper
-
17 min
27. Restoring glucose metabolism: a new approach to reversing cognitive decline in AD- Prof. Katrin Andreasson
-
18 min
28. Advancing ALS genetics through accessible testing- Dr. Teresa Fecteau
-
13 min
29. MicroRNA as a biomarker for early detection of amyotrophic lateral sclerosis- Dr. Sandra Banack
- Dr. Paul Alan Cox
- Dr. Rachael Dunlop
-
25 min
30. Translational research in amyotrophic lateral sclerosis (ALS)- Prof. Aaron D. Gitler
-
20 min
31. Muscarinic acetylcholine receptor modulation in neurological diseases- Prof. Andrew B. Tobin
- Pharmaceutical Sciences
-
19 min
32. The state of the art in secondary pharmacology- Dr. Jean-Pierre Valentin
-
19 min
33. The safety, toxicology, and regulation of antibody-drug conjugates- Dr. Veysel Kayser
-
18 min
-
31 min
35. Management of generic drug development: challenges and opportunities- Mr. Sandeep Patil
-
30 min
36. Translational medicine: the risk of failure in delay and how to reduce it- Prof. Martin Wehling
-
17 min
37. Artificial intelligence in guiding cancer treatment decisions- Prof. Eytan Ruppin
-
13 min
38. The regulation of cell therapy- Prof. Moutih Rafei
-
31 min
39. Scale-up challenges in the production of nanomedicines from lab to industry- Prof. Dr. Oya Tagit
-
8 min
40. Challenges and solutions of scaling up- Dr. Shaukat Ali
-
11 min
-
14 min
42. Using real-world insights on drug interactions to inform drug development- Dr. Amita Datta-Mannan
-
50 min
43. Role of marketing authorization holder in drug safety- Dr. Raphael Elmadjian Pareschi
Topics Covered
- Alzheimer’s disease
- Amyloid
- In vivo disease model
- Dug development
- MEG3
- Necroptosis
- Neuronal cell death
- Pathogenesis
- Stem cell
- Tau pathology.
Biography
Bart De Strooper is professor in dementia research at the University College London, UK. He has been the founding director of the UK Dementia Research Institute (2016-2023) and is now a group leader in the same institute. He is also parttime Professor of molecular medicine at the KU Leuven and VIB, Belgium.
De Strooper’s scientific work focuses on the understanding of the fundamental mechanisms that underlie Alzheimer’s disease. His major findings are the role of ADAM10 and presenilin/gamma-secretase in the proteolysis of the amyloid precursor protein and Notch, and he has worked on microRNA, mitochondria, and more recently on the role of the different brain cell types in the pathogenesis of Alzheimer’s Disease. He developed a novel theory for Alzheimer’s Disease which he called the cellular phase, to explain the long prodromal phase of the disorder. He received his M.D. in 1985 and Ph.D. in 1991 from KU Leuven. He worked as postdoctoral researcher in the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, in the laboratory of Carlos Dotti.
In 2018, Bart De Strooper, together with John Hardy, Christian Haas, and Michel Goedert, was awarded the Brain Prize for their ground-breaking research on the genetic and molecular basis of Alzheimer disease. Other awards include the Potamkin Award of the American Academy of Neurology in 2002 (USA), the 2003 Alois Alzheimer Award of the Deutscher Gesellschaft für Gerontopsychiatrie und psychotherapie (Germany), the Joseph Maisin Prize in 2005 for fundamental biomedical sciences, (FWO Flanders, Belgium), the 2008 Metlife Foundation Award for medical research (USA) and the 2018 European Grand Prix for Research (France).
Links
Series:
Categories:
Therapeutic Areas:
External Links
Talk Citation
De Strooper, B. (2024, June 9). How and why neurons die in Alzheimer's disease? [Audio file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 20, 2026, from https://doi.org/10.69645/JTEQ3247.Export Citation (RIS)
Publication History
- Published on June 9, 2024
Financial Disclosures
- Prof. Bart De Strooper has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Audio Interview
How and why neurons die in Alzheimer's disease?
Published on June 9, 2024
17 min
A selection of talks on Neurology
Transcript
Please wait while the transcript is being prepared...