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1. Introduction
2. Factors related to obesity and mortality
3. BMI and probability of death
4. The elevation in MR in the low BMI
5. Effect of BMI on risk of death given vehicle collision
6. Survival curves for base population and Mr. X
7. YLL at various ages and BMI levels
8. YLL after age 40 due to overweight and obesity
9. Is something wrong with the universe?
10. Weight loss increases life span in mice
11. Impact of bariatric surgery on mortality rate
12. Intentional and unintentional weight lose
13. Is self-described "intentional" WL really intentional
14. Model of intentional weight loss
15. Example of the effects of unintentional weight loss
16. Intentional WL as a latent variable problem
17. Higher weight is associated with increased MR
18. Iconic presentation of WL vs. MR
19. Attributable deaths
20. Annual deaths attributable to overweight problems
21. Effect of age on BMI with lowest MR
22. Excess deaths associated with weight
23. Disparity between two studies
24. Change in reference category
25. A rough breakedown of the reasons for disparity
26. Calle et al. do not find a reduction in RR over time
27. How do we explain Peeters et al. results?
28. How do we explain Fontaine et al. results?
29. Opinion and evidence on these 4 points
30. A non-Bayesian perspective
31. A Bayesian perspective
32. The importance of body composition
33. Using BMI in mortality analyses
34. Body composition and mortality
35. Weight loss vs. fat loss
36. Some key issues for further research
37. Conclusion

Topics Covered

• The relationship between obesity and mortality rate is complex
• Differences in associations and causal effects may exist both within and across species
• Obesity is clearly associated with elevated mortality rate and this association is generally presumed to reflect causation
• The epidemiological evidence regarding the effect of being overweight (but not obese) is less clear and more controversial
• Epidemiological evidence on the effects of weight loss on mortality rate among obese persons is even less clear
• Evidence seems to suggest that weight loss induced by methods generally recommended by the biomedical community will prolong life among obese persons
• Data strongly suggest that losing body fat, as opposed to just body weight, is what conveys the presumed benefit of weight loss on longevity

Links

Series:

• Obesity

Categories:

• Clinical Practice
• Metabolism & Nutrition

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on February 25, 2021

Financial Disclosures

• Prof. David Allison has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.