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Printable Handouts
Navigable Slide Index
- Introduction
- Contents
- Liver: a vital organ
- Role of liver in metabolism
- Metabolic disorders
- Metabolic disorders: obesity
- Metabolic disorders of the liver: NAFLD
- Metabolic disorders of the liver
- Non-alcoholic fatty liver disease
- NAFLD: etiology
- NAFLD: disease progression
- Stages of NAFLD: progression to HCC
- Stages of NAFLD: risk factors
- NAFLD: genetic factors (1)
- NAFLD: genetic factors (2)
- Pathophysiology of NAFLD
- Organs and processes involved in NAFLD pathophysiology
- Pathophysiology of NAFLD: FA mobility
- FA input and FA output in the liver
- Pathophysiology of NAFLD: insulin resistance
- Disturbance of the insulin pathway
- Two hits theory and multiple hits theory
- Pathophysiology of NAFLD: theories
- Pathophysiology of NAFLD: multiple hits
- Pathophysiology of NAFLD: summary
- NAFLD: therapeutic targets
- NAFLD/NASH: therapeutic targets
- NAFLD/NASH: clinical developments
- NAFLD: current management
- Thank you for the attention
Topics Covered
- Liver physiology
- Obesity
- Metabolic diseases of the liver
- Non-Alcoholic Fatty Liver Disease (NAFLD)
- NAFLD progression to Hepatocellular Carcinoma (HCC)
- NAFLD: etiology
- NAFLD: genetic factors
- Pathophysiology of NAFLD
- NAFLD: therapeutic targets
- Clinical developments
Links
Categories:
Therapeutic Areas:
Talk Citation
Khurana, A. (2024, May 30). Non-alcoholic fatty liver disease (NAFLD): etiology, pathogenesis and current therapeutic approaches [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 4, 2024, from https://doi.org/10.69645/BTPJ8671.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Amit Khurana has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Non-alcoholic fatty liver disease (NAFLD): etiology, pathogenesis and current therapeutic approaches
Published on May 30, 2024
22 min
A selection of talks on Metabolism & Nutrition
Transcript
Please wait while the transcript is being prepared...
0:00
I'm Amit Khurana,
a Senior Researcher
working at the
Institute of Molecular Pathobiochemistry,
Experimental Gene Therapy and Clinical Chemistry,
University Hospital Aachen,
RWTH University Aachen,
located in Aachen, Germany.
Today we will learn about
the non-alcoholic
fatty liver disease,
it's etiology, pathology,
and current therapeutic
approaches.
0:24
The contents of the lecture
include the introduction of
liver in normal
physiological functions,
the common metabolic
diseases and their rise.
Some of the most common
metabolic diseases of the liver,
non-alcoholic fatty liver
disease and its etiology,
the pathophysiology of
non-alcoholic fatty
liver disease,
and we will also learn about
the current treatment
options for
non-alcoholic fatty
liver disease.
0:52
The liver is an
important vital organ.
It has remarkable
regeneration potential.
Some of the most important
functions of the liver include
the metabolism of
major nutrients,
maintaining the homeostasis
of blood volume,
the liver has an
active immune system,
which prevents a variety
of systemic infections.
The liver plays
an active role in
the endocrine control
of normal growth.
The liver plays
an important role
in lipid and
cholesterol balance.
The liver is responsible for
the metabolic detoxification
of a variety of xenobiotics.
1:30
The role of the
liver in metabolism:
The liver plays an essential
role in the regulation of
energy homeostasis and controls
important metabolic
processes like
glycolysis, gluconeogenesis,
and fatty acid metabolism.
As the liver plays an important
role in metabolic processes,
unhealthy changes in
dietary patterns may lead
to the dysfunction of
important metabolic processes.
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