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1. Introduction
2. Why is body weight regulated?
3. Adiposity - past and present
4. Gene-environment interactions and body weight
5. Brain regions that regulate body weight
6. Leptin secretion is proportional to body fat
7. Complex CNS interactions in weight regulation
8. Leptin signaling and monogenic forms of obesity
9. Mutations in leptin and its receptor
10. Multiple biological effects of leptin in humans
11. Mutation of the leptin receptor
12. POMC and melanocortin receptor mutations
13. POMC mutation
14. PC1 mutation
15. MC4R mutations result in inherited obesity
16. MC4R mutations cause monogenic obesity
17. Genetic loci of obesity genes
18. Obesity genetics are complex
19. Concordance of obesity - dizygotic twins
20. Concordance of obesity - monozygotic twins
21. Obesity genetics of different populations(1)
22. Obesity genetics of different populations(2)
23. BMI as a function of age, sex and genotype
24. Additive effect of obesity genes mutations
25. Mutations in obesity genes and body fat - mice
26. Leptin threshold effects
27. Bioenergetics of reduced body weight
28. Biological response to changes in leptin levels
29. Is threshold changeable?
30. Neurotrophic effects of leptin exposure
31. Neurotrophic effects of CNTF is similar to leptin's
32. Investigators
33. Thanks

Topics Covered

• Evolutionary arguments for regulation of body fat
• Gene x gene x environment interactions
• Molecular physiology of control of body weight
• Human monogenic obesities
• Complex genetics of human obesity
• Threshold model for control of body weight
• Bioenergetics of reduced body weight
• Structural plasticity in the CNS systems regulating body fat

Links

Series:

• Obesity

Categories:

• Genetics & Epigenetics
• Metabolism & Nutrition

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Leibel, R. (2007, October 1). Understanding obesity: genes and environment in the determination of body weight [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2024, from https://hstalks.com/bs/560/.
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Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. Rudy Leibel has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.