Please wait while the transcript is being prepared...
0:00
Hello everyone. I'm glad you
joining me for this session.
My name is Roland
Stocker and I am
Emeritus Professor and
Distinguished Fellow at the
Hearth Research Institute
in Sydney, Australia.
The topic of today's
presentation is the control of
vascular tone via transformation
of hydrogen peroxide.
0:20
Well, the presentation will
contain four sections.
First, I'll give you
an introduction that
will cover the control
of vascular tone,
what we know about the enzyme
indoleamine 2,3-dioxygenases
or IDO in short,
and L-tryptophan metabolism,
and I will briefly introduce
cellular redox signaling.
We'll then go into some of
the data that we have
produced over the years.
We'll first talk about
the role of IDO1 in
blood pressure control
in human sepsis
and pre-clinical models
of systemic inflammation.
We'll then cover the mechanism
of how IDO1-mediated
arterial relaxation and control
blood pressure lowering.
The final part will deal
with the mechanisms of
the redox signaling by
this molecule
cis-WOOH that we have
identified and that I will
characterize during
the presentation.
1:14
So, let's start with the
regulation of vascular tone.
In principle, the two pathways
by which vascular tone is
regulated is an
extrinsic pathway
and an intrinsic pathway.
The extrinsic pathway
essentially involves
autonomic nervous system
and endocrine system.
I will not be discussing
this pathway.
The intrinsic pathway
includes myogenic tone,
local hormones, and
endothelial-derived factors.
This is really the focus
of this presentation.
Primarily endothelial-derived
factors and
in this diagram, you can see
a blood vessel
with three layers,
the endothelial cell layers
making up the endothelium,
then the layers of
smooth muscle cells,
the number of which
varies depending on
the arterial type we
are talking about,
and then the third layer,
the adventitial cells that
make up the adventitial.
Regulation of
vascular tone really
means that we can have
normal blood pressure
or we can have
vasoconstriction where
the artery decreases
in its diameter,
or we can have a dilated artery
where the diameter of
the artery increases.
It's really this movement
between vasoconstriction and
vasodilation that is
essential for normal
body function.
