• Clinical themes
• 33 min
  1. The clinical features of amyotrophic lateral sclerosis: diagnosis, natural history and epidemiology

  • Prof. Kevin Talbot
• 19 min
  2. Mechanisms of pathogenesis and molecular targets in spinal and bulbar muscular atrophy

  • Dr. Carlo Rinaldi
• Scientific themes
• 39 min
  3. Neuroinflammation in ALS: cause or consequence?

  • Prof. Philip Van Damme
• 44 min
  4. Cognition in ALS and the overlap with frontotemporal dementia (FTD)

  • Dr. Thomas Bak
• 39 min
  5. Large scale genetics of neurodegenerative diseases and ALS

  • Dr. Luc Dupuis
• 26 min
  6. SOD1-related ALS: what has it told us about motor neuron degeneration? - part 1

  • Prof. Dame Pamela Shaw
• 34 min
  7. SOD1-related ALS: what has it told us about motor neuron degeneration? - part 2

  • Prof. Dame Pamela Shaw
• 47 min
  8. Expanding roles of RNA-binding proteins in neurodegenerative diseases

  • Prof. Aaron D. Gitler
• 33 min
  9. Oxidative stress in amyotrophic lateral sclerosis (ALS) 1

  • Prof. Dame Pamela Shaw
• 20 min
  10. Oxidative stress in amyotrophic lateral sclerosis (ALS) 2

  • Prof. Dame Pamela Shaw
• 35 min
  11. Mechanisms of juvenile forms of ALS caused by FUS mutations

  • Dr. Luc Dupuis
• 21 min
  12. Importance of nutrition and weight loss in motor neuron disease

  • Dr. Luc Dupuis

Printable Handouts

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Navigable Slide Index

1. Introduction
2. ALS has a metabolic component: weight loss
3. ALS has a metabolic component
4. ALS mutations impair energy metabolism
5. Outstanding questions
6. Weight loss occurs years before onset of motor symptoms
7. Weight loss is typically observed in ALS mouse models
8. Are weight loss and metabolic abnormalities target for ALS treatment?
9. Weight loss predicts survival
10. High-calorie diet increases survival of ALS mice
11. LIPCAL-ALS
12. Summary: ALS progression is related to weight loss
13. What are the key cell types driving weight loss in ALS?
14. Location of the hypothalamus and its nuclei
15. Hypothalamic structural alterations
16. Hypothalamic volume is correlated to BMI
17. Hypothalamic alterations are mostly found in the LHA
18. MCH neurons degenerate in the LHA
19. Loss of MCH blunts food intake in mutant SOD1 mice
20. Pharmacological strategies?
21. Summary and conclusions
22. Acknowledgment

Topics Covered

• Amyotrophic Lateral Sclerosis (ALS)
• ALS and weight loss
• Progression of ALS
• High-calorie diet
• Hypothalamus in ALS
• Melanin-concentrating hormone (MCH) neurons
• Relationship between MCH neurons, ALS, and weight loss

Links

Series:

• ALS and Other Motor Neuron Disorders

Categories:

• Immunology
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on December 31, 2023

Financial Disclosures

• Dr. Luc Dupuis has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.