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Printable Handouts
Navigable Slide Index
- Introduction
- Human-preferring mosquitoes spread viral diseases
- Some people are more attractive to mosquitoes
- Mosquito magnets and their skin odor
- “Higher” throughput preference assay
- Differentially attractive human skin odor blends
- Mosquito attraction “round robin tournament”
- Which odors are most important?
- IR mutants showed diminished attraction to humans
- Enrichment of acidic compounds on the skin
- The attractiveness level can be diluted
- Conclusions
- Thank you for listening!
Topics Covered
- Differential mosquito attraction to humans
- Skin-derived carboxylic acid levels
- Aedes aegypti
- Anopheles gambiae
- Human odorants
- Odorant Receptors (ORs)
- Ionotropic Receptors (IRs)
- Mosquito preference assay
- Orco, Ir8a, Ir76b, Ir25a mutants
Talk Citation
De Obaldia, M.E. (2023, October 31). Differential mosquito attraction to humans [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 7, 2024, from https://doi.org/10.69645/PLRR7766.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Maria Elena De Obaldia has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Immunology & Inflammation
Transcript
Please wait while the transcript is being prepared...
0:00
My name is Maria
Elena De Obaldia.
Today, I'll be
speaking to you about
my research on differential
mosquito attraction to
humans and how this
is associated with
the levels of carboxylic
acids on the skin.
This research was
conducted in New York at
the Rockefeller
University during
my postdoctoral fellowship.
0:25
The reason we are so interested
in understanding why
some humans are more
attractive to mosquitoes than
others is because mosquitoes
spread viral diseases that
sicken hundreds of thousands
of people per year.
Two of the major culprits
for the spread of
mosquito-borne diseases
are pictured here.
These are female
mosquitoes of the species
Aedes aegypti and
Anopheles gambiae.
Aedes aegypti mosquitoes
are the ones used in
this study and they're
responsible for
spreading Yellow fever,
Dengue, Zika, and Chikungunya.
The Anopheles gambiae female is
the major vector of Malaria,
which causes about
500,000 deaths per year.
I want to note that only
female mosquitoes bite humans
and they do this because
they need to obtain
protein from our blood
in order to lay eggs.
1:28
You've probably noticed
in your everyday life
that some people seem to get
many more mosquito
bites than others.
We wanted to study
this in the lab.
We're not the first
people to do so.
Several other groups
have studied this
in both field environments
and laboratory environments.