Adult growth hormone deficiency: current understanding, diagnosis and treatment

Published on September 28, 2023   36 min

A selection of talks on Reproduction & Development

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0:00
Hello. My name is Kevin Yuen. I'm the Professor of Medicine and Medical Director of the Barrow Neurological Institute, Pituitary Center in Phoenix, Arizona. Today my talk to you is titled, Adult Growth Hormone Deficiency: Current Understanding Diagnosis and Treatment.
0:20
These are my disclosures.
0:24
So for my talk today, I would like to start off with a case example of a patient that presented to me recently with adult onset growth hormone deficiency. He's a 54 year old male with Non-Functioning Pituitary Adenoma, underwent pituitary surgery four years ago, and stereotactic radiosurgery three years ago. Now he has underlying TSH and ACTH deficiencies, for which he is on stable doses of levothyroxine and hydrocortisone. At his most recent clinic follow up appointment, he had a blood test where his IGF one standard deviation score was -1.7. His main complaint now is that he's noticing some weight gain of ten pounds over the past six months and increased fatigue. He does have a family history of osteoporosis, hyperlipidemia and cancer. He has read up on the Internet about the condition called adult growth hormone deficiency and would like to be considered for treatment for this.
1:23
For this patient, what are the discussion points that one needs to be considering when seeing this patient? On this slide here you can see that the condition adult growth hormone deficiency and why treat it certainly something that needs to be addressed then followed by who to screen, how to screen, and once the patient has confirmed adult growth hormone deficiency, how to start growth hormone therapy, and how to monitor treatment efficacy. There's also the issue of discussing with the patient about potential safety concerns with long term growth hormone replacement and also potential use or misuse of growth hormone replacement for anti aging purposes.

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Adult growth hormone deficiency: current understanding, diagnosis and treatment

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