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              Printable Handouts
Navigable Slide Index
- Introduction
 - Vaccine hesitancy (1)
 - Opposition to vaccines
 - Vaccine hesitancy (2)
 - The vaccine hesitancy continuum
 - Vaccine hesitancy (3)
 - Determinants of vaccine hesitancy
 - Concerns vary by vaccine, time, context, and country
 - The state of vaccine confidence in the world
 - Vaccine confidence changes over time
 - How do we make decisions?
 - Two decision-making processes
 - Two ways to process risks
 - How do people decide to vaccinate or not?
 - Vaccination: decision making in a context of increasing and complex technologies
 - Trust in science and vaccine confidence
 - The concept of trust asymmetry
 - Trust in the internet
 - The role of misinformation
 - COVID-19, scientific literacy and misinformation
 - Polarization, politics and populism
 - Individual liberties vs. safeguarding public health
 - Improving vaccine confidence
 - Listening to the public: no single metric tells the story
 - Moving beyond the knowledge-deficit model
 - How to communicate to restore trust?
 - Communication techniques for healthcare professionals facing hesitant parents
 - Motivational interviewing: a 4-step process
 - Preparation and learning from our mistakes
 - Conclusion
 - Thank you!
 
Topics Covered
- Vaccine hesitancy
 - Vaccine confidence
 - Decision making processes
 - Trust asymmetry
 - Misinformation
 - COVID-19
 - Polarization, politics and populism
 - Beyond the knowledge-deficit model
 - Communication techniques
 - Motivational interviewing
 
Talk Citation
Karafillakis, E. (2023, August 31). Vaccine hesitancy: challenges and solutions [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 3, 2025, from https://doi.org/10.69645/AGAX2303.Export Citation (RIS)
Publication History
- Published on August 31, 2023
 
Financial Disclosures
- Emilie Karafillakis has received funding for research grants allocated to the Vaccine Confidence Project from Astra Zeneca, Janssen Pharmaceutica NV, Merck Sharp & Dohme Limited, and GlaxoSmithKlein.
 
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Transcript
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                  0:00
                
                
                  
                    Hello. My name is
Emilie Karafillakis,
                  
                    I am the European Director at
                  
                    the Vaccine Confidence
Project which stays both at
                  
                    the London School of Hygiene
and Tropical Medicine in
                  
                    the UK and at the University
of Antwerp in Belgium.
                  
                    I will be talking to you today
about vaccine hesitancy,
                  
                    its challenges, and solutions.
                  
                
              
                  0:20
                
                
                  
                    Vaccine hesitancy
is not a new issue.
                  
                    We actually know that
                  
                    the first group that were
against vaccines were
                  
                    developed during
the first vaccine
                  
                    that existed for the
vaccine against smallpox,
                  
                    and there are report and records
                  
                    of vaccination sentiments that
                  
                    date back to this time.
                  
                    You can see here one of these
very first images that were
                  
                    circulating at the time which
                  
                    was propaganda
against vaccination.
                  
                    You can see there
what's called the
                  
                    vaccination monster that was
                  
                    eating babies alive and they
                  
                    were coming out with
horns on their head.
                  
                    This was a symbol that
smallpox vaccination that was
                  
                    created based on cowpox was
                  
                    dangerous and potentially
leading side-effects
                  
                    like babies
transforming into cows.
                  
                    It's not new, has
it changed though?
                  
                    Well, not really.
                  
                
              
                  1:14
                
                
                  
                    We know that back in the days in
                  
                    the 19th century with
                  
                    the very first vaccine
against smallpox,
                  
                    people had opposition
against vaccines
                  
                    that were very similar to
                  
                    the ones that we're
seeing today,
                  
                    for example, there was
                  
                    resistance against
compulsory vaccination.
                  
                    People did not understand
exactly how vaccines work,
                  
                    how vaccination
can protect them.
                  
                    There were some religious
and philosophical
                  
                    concerns as well
                  
                    circulating and beliefs
that vaccination
                  
                    could be unsafe or ineffective.
                  
                    Very much the same
type of opposition
                  
                    and concern or beliefs
that we see today.