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Printable Handouts
Navigable Slide Index
- Introduction
- Outlines
- Cells: need for forces
- Tissues: need for forces
- Tissue repair and regeneration
- An inspirational study
- Morphology of osteoblast filopodia formed on distinct topographies
- Filopodial extension on disordered topography of NCD
- Filopodial extension on disordered topography of MCD
- How to explain these phenomena?
- Modeling filopodial growth dynamics on biomaterial surface
- Predicted morphology of a filopodium extending on MCD topography
- Predicted moving trajectory and velocity of filopodial on disordered surface
- Validation: cell functions on diamond coatings
- Validation study: osteoblast functions mediated by diamond coating morphology
- In vivo verification (by AA Rodrigues, Brazil)
- Mechano-active biomaterials: hypothesis
- Pilot study
- Myocardial Infarction (MI) and its treatments
- A mechano-active approach to treating MI ?
- Finite-element modeling
- Simulation-optimized mechanical properties
- An optimized mechano-active gel
- GPAP stays at the “GEL POINT”
- GPAP is mechanically self-adaptive to beating heart
- In vivo study by rat acute MI model
- GPAP improves heart function after acute MI
- GPAP reverses LV remodeling after acute MI
- GPAP improves LV systolic and diastolic functions after acute MI
- GPAP reduces myocyte hypertrophy after acute MI
- GPAP improves heart functions after sub-acute MI
- GPAP reverse heart remodeling after sub-acute MI
- GPAP demonstrates a new mechanical reconstruction approach to treat MI
- Summary: mechano-active biomaterials
- Acknowledgements
- Thank you!
Topics Covered
- Tissue repair and regeneration
- Filopodial growth dynamics
- Mechano-active biomaterials
- Myocardial Infarction treatment
- Gel-point adhesive patch (GPAP)
- Disordered topography
- Finite-element modeling
- Mediated osteoblast migration and differentiation
- Diamond coating morphology
- In vivo verification
- Viscoelastic adhesive epicardial patch
Links
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External Links
Talk Citation
Yang, L. (2023, May 31). Mechano-active biomaterials for tissue repair and regeneration [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 21, 2024, from https://doi.org/10.69645/CIOF8173.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Lei Yang has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Other Talks in the Series: Nanomedicine
Transcript
Please wait while the transcript is being prepared...
0:00
Hello everyone.
This is Lei from
the School of Health Sciences
and Biomedical Engineering
at Hebei University
of Technology.
It is my great
pleasure to present at
the Henry Stewart talks
to share with you
our recent research on
the mechanical
active biomaterials
for tissue repair
and regeneration.
This is work we have been
working for many years.
Based on a very simple idea that
if you can create
a biomaterial that
helps to actively respond to the
in vivo mechano or
mechanical response,
this material can give you
very special effects,
in helping tissue repair
and regeneration.
0:47
Today my talk is going to
cover the following parts.
We will first
introduce background
on how important the force is,
the force or stress,
how important it is in cells and
tissues and also in the process
of tissue regeneration.
Then I will just share with you
an inspirational
study I had been
conducting when I
was a Ph.D. student,
to show you why we
are thinking of
reconstructing mechano-active
biomaterials or
creating something that is
automatically a response to in
vivo mechanical
environments, which is
really helpful to
tissue regeneration.
Then, I will propose
the hypothesis or
maybe the definition of
mechano-active biomaterials.
Then I will give
you a pilot study
to show you how these,
what we call mechano-active
biomaterials, could help
tissue regeneration,
like the treatments
for the myocardial infarction.
And last, I would like
to summarize this study.